| Cat. No. |
Product Name |
Information |
| PC-21317 |
SWTX-143
TEAD inhibitor
|
SWTX-143 is a potent, irreversible and covalent YAP/TAZ-TEAD inhibitor with IC50 of 12 nM in luciferase reporter assays, binds to the palmitoylation pocket of all four TEAD isoforms, inhibits Hippo pathway-mutant cancer cells. |
| PC-20801 |
IAG933
YAP-TEAD inhibitor
|
IAG933 (IAG-933) is a potent, selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor (YAP/TAZ-TEADs PPI), inhibits TEAD-driven transcriptional activity and displays anti-cancer effects. |
| PC-20409 |
TEAD activator Q2
TEAD activator
|
TEAD activator Q2 (Quinolinol Q2) is a small molecule activator of TEAD with EC50 of 2.6 uM in TEAD dual-luciferase reporter (DLR) assays, inhibits TEAD-palmitate interaction with IC50 of 1.7 uM. |
| PC-20407 |
GNE-7883
TEAD inhibitor
|
GNE-7883 (GNE7883) is a potent, reversible, allosteric inhibitor of the YAP1-TEAD interaction. |
| PC-20406 |
IK-930
TEAD inhibitor
|
IK-930 (IK930) is a selective, oral TEAD inhibitor that selectively inhibits TEAD-dependent transcription by directly blocking autopalmitoylation. |
| PC-49697 |
TED-642
TEAD-YAP1 inhibitor
|
TED-642 (TED642) is a potent, covalent, pan-TEAD-YAP1 antagonist, inhibits TEAD1/2/4 binding to YAP with IC50 of 0.9-1.2 uM. |
| PC-49541 |
MGH-CP1
TEAD inhibitor
|
MGH-CP1 is a specific small molecule TEAD palmitoylation inhibitor, exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively. |
| PC-49540 |
VT-105
TEAD inhibitor
|
VT-105 (VT105) is a highly potent and selective TEAD inhibitor, selectively inhibit YAP/TAZ-TEAD promoted gene transcription with IC50 of 10.4 nM in YAP reporter assays, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. |
| PC-49537 |
TEAD inhibitor TM2
pan-TEAD inhibitor
|
TEAD inhibitor TM2 is a potent pan-TEAD auto-palmitoylation inhibitor with IC50 of 156 and 38 nM for TEAD2 palmitoylation and TEAD4 auto-palmitoylation, respectively, disrupts TEAD-YAP association and specifically inhibits YAP transcriptional activities. |
| PC-49408 |
MYF-03-69
YAP-TEAD inhibitor
|
MYF-03-69 is a selective, covalent, irreversible TEAD inhibitor, binds with TEAD palmitate pocket, disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=45 nM) and inhibits cell growth of defective Hippo signaling. |
| PC-49407 |
MYF-03-176
YAP-TEAD inhibitor
|
MYF-03-176 is a potent and orally bioavailable MYF-03-69 analog, pan-TEAD inhibitor that disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=11 nM). |
| PC-47086 |
MSC-4106
TEAD inhibitor
|
MSC-4106 is a potent, in vivo active inhibitor of TEAD transcription factor with IC50 of 4 and 14 nM in SK-HEP1 reporter and NCI-H226 viability assays, respectively. |
