| Cat. No. |
Product Name |
Information |
| PC-22052 |
BAY-6092
YAP1/TAZ inhibitor
|
BAY-6092 (BAY6092) is a potent, selective YAP1/TAZ pathway inhibitor with IC50 of 1.6 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex. |
| PC-22051 |
BAY-856
YAP1/TAZ inhibitor
|
BAY-856 (BAY856) is a potent, selective YAP1/TAZ pathway inhibitor with IC50 of 49 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex. |
| PC-22050 |
BAY-593
YAP1/TAZ inhibitor
|
BAY-593 (BAY593) is a potent, selective, in vivo-active YAP1/TAZ pathway inhibitor with IC50 of 9.4 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex. |
| PC-21290 |
mCMY020
TEAD inhibitor
|
mCMY020 is a potent, specific and covalent inhibitor of TEAD transcriptional activity with IC50 of 91.9-468.6 nM for TEAD1-4. |
| PC-21253 |
AF-2112
TEAD inhibitor
|
AF-2112 is a small molecule inhibitor of TEAD, reduces the expression of CTGF, Cyr61, Axl and NF2, inhibits migration of human MDA-MB-231 breast cancer cells. |
| PC-21252 |
TEAD inhibitor LM41
TEAD inhibitor
|
TEAD inhibitor LM41 is a small molecule inhibitor of TEAD, reduces the expression of CTGF, Cyr61, Axl and NF2, inhibits migration of human MDA-MB-231 breast cancer cells. |
| PC-20408 |
NSC682769
YAP-TEAD inhibitor
|
NSC682769 is a specific YAP-TEAD signaling inhibitor, blocks the association of the YAP and TEAD interaction interface, directly binds to YAP with Kd of 738 nM. |
| PC-20405 |
TEAD inhibitor 6
TEAD inhibitor
|
TEAD inhibitor 6 is a highly potent TEAD inhibitor, disrupts the YAP-TEAD interaction with IC50 of 2.7 nM, binds the main interaction site of YAP at the surface of TEAD. |
| PC-49416 |
YAP inhibitor JM7
YAP-TEAD inhibitor
|
JM7 is a small-molecule that inhibits TEAD palmitoylation and stability, affects YAP-TEAD interaction and inhibits YAP transcriptional activity and impairs proliferation, colony formation and migration of breast and ovarian cancer cells. |
| PC-49185 |
TAT-PDHPS1
YAP inhibitor
|
TAT-PDHPS1 is an endogenous stable peptide that inhibits the proliferation of ovarian cancer cells in vitro, regulates ovarian cancer development through targeting YAP1 signaling, binds to and interacts with protein phosphatase 2 phosphatase activator (PTPA). |
| PC-49184 |
PDHPS1
YAP inhibitor
|
PDHPS1 is an endogenous stable peptide which is derived from the C-terminal (2090-2110) of NUMA1, inhibits the proliferation of ovarian cancer cells in vitro, regulates ovarian cancer development through targeting YAP1 signaling, binds to and interacts with protein phosphatase 2 phosphatase activator (PTPA). |
| PC-73283 |
DC-TEAD3in03
TEAD3 inhibitor
|
DC-TEAD3in03 is a potent, selective, covalent TEAD3 inhibitor with IC50 of 0.16 uM, 100-fold selectivity over other TEAD isoforms (IC50>20 uM) in ABPP assays. |
