| Cat. No. |
Product Name |
Information |
| PC-72171 |
K-975
TEAD inhibitor
|
K-975 (K975, YAP1-TEAD inhibitor K975) is a potent, specific inhibitor of YAP1/TAZ-TEAD signaling, inhibits YAP1/TAZ-TEAD protein-protein interaction, a pan-TEAD inhibitor binds to Cys359 of TEAD1-YBD. |
| PC-38304 |
YAP activator PY-60
YAP activator
|
YAP activator PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2). |
| PC-38143 |
TEAD-IN-2
TEAD antagonist
|
TEAD-IN-2 (TEAD antagonist 2) is a small molecule TEAD antagonist (TEAD2 IC50=603 nM FP assays, SPR Kd=229 nM) that binds the TEAD lipid pocket and disrupts TEAD S-palmitoylation. |
| PC-36118 |
Verteporfin
YAP inhibitor
|
Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer. |
| PC-36034 |
IBS003031
YAP1 activator
|
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays. |
| PC-35898 |
TED-347
YAP-TEAD4 inhibitor
|
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity. |
| PC-35820 |
TT-10
YAP-TEAD activator
|
TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes. |
| PC-60375 |
YAP1 inhibitor CA3
YAP1 inhibitor, Ferroptosis inducer
|
YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/TEAD transcriptional activity |
| PC-23994 |
BPI-460372
TEAD inhibitor
|
BPI-460372 is a potent, orally available, covalent, irreversible inhibitor of TEAD1/3/4, irreversibly binds to the cysteine residue in the TEAD palmitoylation pocket, preventing TEAD palmitoylation and inhibiting its biological function. |
| PC-23670 |
M3686
TEAD1 inhibitor
|
M3686 is a potent, selective TEAD1 inhibitor with IC50 of 51 nM in TEAD reporter assay, shows weaker binding to TEAD3, and negligible activity on TEAD2 and TEAD4. |
| PC-23232 |
MSC-1254
TEAD1 inhibitor
|
MSC-1254 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 1 uM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 0.04 uM. |
| PC-23231 |
MSC-5046
TEAD1 inhibitor
|
MSC-5046 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 58 nM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 12 nM. |
