| Cat. No. |
Product Name |
Information |
| PC-72506 |
VT103
TEAD1 inhibitor
|
VT103 (VT-103) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 1.2 nM in YAP reporter assay, selectively blocks TEAD1 auto-palmitoylation. |
| PC-72427 |
LM98
YAP-TEAD inhibitor
|
LM98 (TEAD inhibitor LM98) is a flufenamic acid analogue, shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. |
| PC-72171 |
K-975
YAP-TEAD inhibitor
|
K-975 (K975, YAP1-TEAD inhibitor K975) is a potent, specific inhibitor of YAP1/TAZ-TEAD signaling, inhibits YAP1/TAZ-TEAD protein-protein interaction, a pan-TEAD inhibitor binds to Cys359 of TEAD1-YBD. |
| PC-38304 |
Annexin A2 inhibitor PY-60
ANXA2 inhibitor, YAP activator
|
Annexin A2 inhibitor PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2). |
| PC-38143 |
TEAD inhibitor Compound 2
TEAD antagonist
|
TEAD inhibitor Compound 2 (TEAD-IN-2) is a small molecule TEAD antagonist (TEAD2 IC50=603 nM FP assays, SPR Kd=229 nM) that binds the TEAD lipid pocket and disrupts TEAD S-palmitoylation. |
| PC-36118 |
Verteporfin
YAP inhibitor
|
Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer. |
| PC-36034 |
IBS003031
YAP1 activator
|
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays. |
| PC-35898 |
TED-347
YAP-TEAD4 inhibitor
|
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity. |
| PC-35820 |
TT-10
YAP activator
|
TT-10 (YAP-TEAD activator TT-10, TAZ-K) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes. |
| PC-60375 |
YAP1 inhibitor CA3
YAP1 inhibitor, Ferroptosis inducer
|
YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/TEAD transcriptional activity |
| PC-27397 |
AZ4331
YAP-TEAD inhibitor
|
AZ4331 (AZ'4331) is a potent, covalent pan-TEAD palmitoylation inhibitor, exhibits target engagement in the TEAD central pocket with IC50 of 381 nM, 20 nM, 14 nM and 31 nM for TEAD1, TEAD2, TEAD3 and TEAD4 in biochemical TEAD-TR-FRET assays, inhibits YAP-TEAD binding and TEAD-dependent transcription. |
| PC-27157 |
M511-0965
YAP-TEAD4 inhibitor
|
M511-0965 is a small-molecule inhibitor of YAP-TEAD4, binds directly to TEAD4 with MST Kd of 2.76 uM, shows growth inhibition in MDA-MB-231 cells with IC50 of 1.135 uM. |
