| Cat. No. |
Product Name |
Information |
| PC-27127 |
GNE-2181
pan-TEAD inhibitor
|
GNE-2181 is a potent, selective, covalent, orally bioavailable and brain-penetrant pan-TEAD inhibitor, disrupts YAP-TEAD interaction with biochemical IC50s of 2/4/8/6 nM for TEAD1/2/3/4 in TR-FRET assays. |
| PC-26706 |
LC-TEAD01
TEAD inhibitor
|
LC-TEAD01 is a potent, selective and covalent TEAD inhibitor with IC50 of 116 nM for TEAD1, inhibits TEAD1-YAP peptide binding with IC50 of 48.29 nM. |
| PC-26510 |
TED-655
TEAD-YAP1 inhibitor
|
TED-655 is a small-molecule covalent inhibitor of TEAD-YAP1 transcription factor, reduces TEAD and YAP1 protein levels. |
| PC-26277 |
VT3989
YAP/TEAD inhibitor
|
VT3989 is a first-in-class, orally bioavailable, selective and potent inhibitor of YAP/TEAD inhibitor, inhibits TEAD autopalmitoylation and disrupts YAP transcriptional activity. |
| PC-26276 |
YAP1-TEAD inhibitor MRK-A
YAP/TEAD inhibitor
|
MRK-A is a highly potent, selective, orally bioavailable inhibitor of YAP1/TEAD with EC50 of 3.4 nM in cellular MCF7 assay expressing TEAD-reporter luciferase, inhibits TEAD palmitoylation that leads to allosteric YAP1/TEAD complex disruption. |
| PC-25992 |
MSC-4070
TEAD inhibitor
|
MSC-4070 is a selective, brain-penetrant TEAD1/2/4 inhibitor with IC50 of 14 nM in TEAD reporter assays in SK-HEP-1 cells, with selectivity for TEAD1, 2, 4 over TEAD3, has IC50 of 30 nM in NCI-H226 viability assays. |
| PC-24744 |
Cyclovirobuxine D
YAP inhibitor
|
Cyclovirobuxine D (CVB-D) is a naturally alkaloid, induces autophagy and attenuates the phosphorylation of Akt and mTOR, exerts its anti-cancer effects by directly binding to YAP, inhibits the nuclear translocation of YAP/TAZ and suppresses the transcription of downstream oncogenic target genes. |
| PC-24521 |
TJ-M11
YAP/TAZ inhibitor
|
TJ-M11 is a synthesized peptide inhibitor of YAP/TAZ transactivation domain (TAD), specifically blocks YAP transactivation (IC50=5.96 uM, NCI-H1299 cells) by disrupting its TAD interactions with the cofactors MED15 and TAF4. |
| PC-24392 |
GL-V9
YAP1 inhibitor
|
GL-V9 is synthetic flavonoid derivative that possess an antitumor effect, effectively promotes the degradation of YAP1, reduces YAP1 nuclear localization, and induces mitochondrial apoptosis in PDAC cells, also induce apoptosis of CML cells via MAPK signaling pathway. |
| PC-23670 |
M3686
TEAD1 inhibitor
|
M3686 is a potent, selective TEAD1 inhibitor with IC50 of 51 nM in TEAD reporter assay, shows weaker binding to TEAD3, and negligible activity on TEAD2 and TEAD4. |
| PC-23232 |
MSC-1254
TEAD1 inhibitor
|
MSC-1254 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 1 uM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 0.04 uM. |
| PC-23231 |
MSC-5046
TEAD1 inhibitor
|
MSC-5046 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 58 nM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 12 nM. |
