| Cat. No. |
Product Name |
Information |
| PC-24744 |
Cyclovirobuxine D
YAP inhibitor
|
Cyclovirobuxine D (CVB-D) is a naturally alkaloid, induces autophagy and attenuates the phosphorylation of Akt and mTOR, exerts its anti-cancer effects by directly binding to YAP, inhibits the nuclear translocation of YAP/TAZ and suppresses the transcription of downstream oncogenic target genes. |
| PC-24521 |
TJ-M11
YAP/TAZ inhibitor
|
TJ-M11 is a synthesized peptide inhibitor of YAP/TAZ transactivation domain (TAD), specifically blocks YAP transactivation (IC50=5.96 uM, NCI-H1299 cells) by disrupting its TAD interactions with the cofactors MED15 and TAF4. |
| PC-24392 |
GL-V9
YAP1 inhibitor
|
GL-V9 is synthetic flavonoid derivative that possess an antitumor effect, effectively promotes the degradation of YAP1, reduces YAP1 nuclear localization, and induces mitochondrial apoptosis in PDAC cells, also induce apoptosis of CML cells via MAPK signaling pathway. |
| PC-23994 |
BPI-460372
TEAD inhibitor
|
BPI-460372 is a potent, orally available, covalent, irreversible inhibitor of TEAD1/3/4, irreversibly binds to the cysteine residue in the TEAD palmitoylation pocket, preventing TEAD palmitoylation and inhibiting its biological function. |
| PC-23670 |
M3686
TEAD1 inhibitor
|
M3686 is a potent, selective TEAD1 inhibitor with IC50 of 51 nM in TEAD reporter assay, shows weaker binding to TEAD3, and negligible activity on TEAD2 and TEAD4. |
| PC-23232 |
MSC-1254
TEAD1 inhibitor
|
MSC-1254 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 1 uM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 0.04 uM. |
| PC-23231 |
MSC-5046
TEAD1 inhibitor
|
MSC-5046 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 58 nM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 12 nM. |
| PC-23121 |
DC-TEADin02
TEAD inhibitor
|
DC-TEADin02 is a potent, selective, covalent TEAD autopalmitoylation inhibitor with IC50 of 197 nM, shows minimal effect on TEAD-YAP interaction. |
| PC-23113 |
YAP-TEAD inhibitor BY03
YAP-TEAD inhibitor
|
BY03 is a small molecule inhibitor of YAP-TEAD interaction with IC50 of 1.5 uM in TEAD-dependent luciferase assay in overexpressing the TEAD luciferase plasmid in HEK293T. |
| PC-22052 |
BAY-6092
YAP1/TAZ inhibitor
|
BAY-6092 (BAY6092) is a potent, selective YAP1/TAZ pathway inhibitor with IC50 of 1.6 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex. |
| PC-22050 |
BAY-593
YAP1/TAZ inhibitor
|
BAY-593 (BAY593) is a potent, selective, in vivo-active YAP1/TAZ pathway inhibitor with IC50 of 9.4 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex. |
| PC-21253 |
AF-2112
TEAD inhibitor
|
AF-2112 is a small molecule inhibitor of TEAD, reduces the expression of CTGF, Cyr61, Axl and NF2, inhibits migration of human MDA-MB-231 breast cancer cells. |
