| Cat. No. |
Product Name |
Information |
| PC-25822 |
PCI-27483
FVIIa inhibitor, hCA IX/hCA XII inhibitor
|
PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2. |
| PC-25270 |
FC-531
Carbonic anhydrase inhibitor
|
FC-531 is a highly potent carbonic anhydrase (CA) inhibitor with Ki values of 6.2 nM and 2.3 nM for the transmembrane and tumor-associated isoforms CA IX and CA XII. |
| PC-24458 |
Ethoxzolamide
Carbonic anhydrase inhibitor
|
Ethoxzolamide (Redupresin, L-643786, PNU-4191) is a potent carbonic anhydrase inhibitor with Ki values of 25, 8, 93, 34 and 22 nM for isozymes hCA I, hCA II, hCA IV, hCA IX, and hCA XII respectively. |
| PC-24455 |
Brinzolamide
CA II inhibitor
|
Brinzolamide (AL-4862) is a potent, selective carbonic anhydrase II (CA II) inhibitor with IC50 of 3.2 nM, reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. |
| PC-23741 |
VD11-4-2
CA IX inhibitor
|
VD11-4-2 is a high affinity, selectivity inhibitor of carbonic anhydrase IX (CA IX) with ITC Kd of 15 pM, with remarkable selectivity over other CA isozymes. |
| PC-23739 |
AZ19-3-2
CA IX inhibitor
|
AZ19-3-2 is a high affinity, dual-head inhibitor of carbonic anhydrase IX (CA IX) with binding Kd of 25 pM in thermal shift assays, binds two CA IX catalytic domains on the cell surface simultaneously. |
| PC-22967 |
Acetazolamide
CA IX inhibitor
|
Acetazolamide is a potent carbonic anhydrase IX (CA IX) inhibitor with an IC50 of 30 nM for hCA IX. |
| PC-62314 |
Indisulam
Carbonic Anhydrase inhibitor
|
Indisulam (E7070) is potent, sulfonamide, carbonic anhydrase inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines. |
| PC-70028 |
SLC-0111
CA IX/CA XII inhibitor
|
SLC-0111 (U-104) is a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor with IC50 of 45 nM and 4.5 nM for tumor-associated enzymes hCA IX and hCA XII. |
| PC-27812 |
Benzthiazide
Carbonic anhydrase inhibitor
|
Benzthiazide is a long-acting diuretic and hypertension agent, also inhibits carbonic anhydrase 9 (CA9) with Ki of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. |
| PC-27244 |
BE21417
hCA IX/XII inhibitor
|
BE21417 is a potent, selective dual inhibitor of carbonic anhydrases hCA IX and XII, exhibits a nearly 6-fold preference for hCA XII over hCA II. |
| PC-27243 |
BE21349
hCA IX/XII inhibitor
|
BE21349 is a potent, selective dual inhibitor of carbonic anhydrases hCA IX and XII with Ki of 61.8 nM and 40.5 nM for hCA IX and hCA XII respectively. |
