| Cat. No. |
Product Name |
Information |
| PC-25270 |
FC-531
Carbonic anhydrase inhibitor
|
FC-531 is a highly potent carbonic anhydrase (CA) inhibitor with Ki values of 6.2 nM and 2.3 nM for the transmembrane and tumor-associated isoforms CA IX and CA XII. |
| PC-24458 |
Ethoxzolamide
Carbonic anhydrase inhibitor
|
Ethoxzolamide (Redupresin, L-643786, PNU-4191) is a potent carbonic anhydrase inhibitor with Ki values of 25, 8, 93, 34 and 22 nM for isozymes hCA I, hCA II, hCA IV, hCA IX, and hCA XII respectively. |
| PC-24455 |
Brinzolamide
CA II inhibitor
|
Brinzolamide (AL-4862) is a potent, selective carbonic anhydrase II (CA II) inhibitor with IC50 of 3.2 nM, reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. |
| PC-23741 |
VD11-4-2
CA IX inhibitor
|
VD11-4-2 is a high affinity, selectivity inhibitor of carbonic anhydrase IX (CA IX) with ITC Kd of 15 pM, with remarkable selectivity over other CA isozymes. |
| PC-23739 |
AZ19-3-2
CA IX inhibitor
|
AZ19-3-2 is a high affinity, dual-head inhibitor of carbonic anhydrase IX (CA IX) with binding Kd of 25 pM in thermal shift assays, binds two CA IX catalytic domains on the cell surface simultaneously. |
| PC-22967 |
Acetazolamide
CA IX inhibitor
|
Acetazolamide is a potent carbonic anhydrase IX (CA IX) inhibitor with an IC50 of 30 nM for hCA IX. |
| PC-62314 |
Indisulam
Carbonic Anhydrase inhibitor
|
Indisulam (E7070) is potent, sulfonamide, carbonic anhydrase inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines. |
| PC-70028 |
SLC-0111
CA IX/CA XII inhibitor
|
SLC-0111 (U-104) is a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor with IC50 of 45 nM and 4.5 nM for tumor-associated enzymes hCA IX and hCA XII. |
| PC-27812 |
Benzthiazide
Carbonic anhydrase inhibitor
|
Benzthiazide is a long-acting diuretic and hypertension agent, also inhibits carbonic anhydrase 9 (CA9) with Ki of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. |
| PC-27244 |
BE21417
hCA IX/XII inhibitor
|
BE21417 is a potent, selective dual inhibitor of carbonic anhydrases hCA IX and XII, exhibits a nearly 6-fold preference for hCA XII over hCA II. |
| PC-27243 |
BE21349
hCA IX/XII inhibitor
|
BE21349 is a potent, selective dual inhibitor of carbonic anhydrases hCA IX and XII with Ki of 61.8 nM and 40.5 nM for hCA IX and hCA XII respectively. |
| PC-26516 |
CAIX inhibitor S4
CA IX/CAXII inhibitor
|
CAIX inhibitor S4 is a potent, specific CA IX/XII inhibitor with Ki of 7 nM and 2 nM for human CA IX (CA9) and CA XII (CA12) respectively, much weakly inhibits CA II and CA I, inhibits lung metastasis in orthotopic MDA-MB-231 mouse model. |
