| Cat. No. |
Product Name |
Information |
| PC-21914 |
CHI3L1 inhibitor 30
CHI3L1 inhibitor
|
CHI3L1 inhibitor 30 is a potent, selective chitinase-3-like-1 (CHI3L1, YKL-40) inhibitor with IC50 of 50 nM, with little to no activity against hCHIT1 and hAMCase (IC50=6500 and 964 nM). |
| PC-47042 |
K284
CHI3L1 inhibitor
|
K284 (K284-6111) is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals. |
| PC-38628 |
OATD-01
Chitinase-1 inhibitor
|
OATD-01 (GLPG4716) is a highly potent, orally active chitinase-1 (CHIT1) inhibitor with IC50 of 26 (hCHIT1) and 29 nM (mCHIT1), inhibits hAMCase and mAMCase with IC50 of 9.0 and 7.8 nM, respectively. |
| PC-72373 |
Wyeth-1
hAMCase inhibitor
|
Wyeth-1 (hAMCase inhibitor 1) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 210 nM, 20-fold selectivity over hCHIT1. |
| PC-72372 |
OAT-1441
hAMCase inhibitor
|
OAT-1441 (OAT1441) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 7 nM. |
| PC-62540 |
OAT-177
Chitinase inhibitor
|
OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1. |
| PC-62539 |
OAT-2068
mCHIT1 inhibitor
|
OAT-2068 is a potent, selective, orally bioavailable inhibitor of mouse chitotriosidase (mCHIT1) with IC50 of 29 nM, 143-fold selectivity over mAMCase. |
| PC-25397 |
CHI3L1 inhibitor 1-7
CHI3L1 inhibitor
|
CHI3L1 inhibitor 1-7 is potent CHI3L1 binder with KD of 7.4 uM, inhibits the interaction between CHI3L1 and galectin-3 with IC50 of 15.4 uM, reduces GBM spheroid viability and inhibits STAT3 activation. |
| PC-25373 |
CHI3L1 inhibitor 9e
CHI3L1 inhibitor
|
CHI3L1 inhibitor 9e is a small molecule inhibitor of Chitinase 3-like 1 (CHI3L1) with SPR KD of 19.11 uM, inhibits CHI3L1-STAT3 axis and elicits a dose-dependent reduction in pSTAT3 in GBM spheroids. |
| PC-24878 |
CHI3L1 inhibitor 11g
CHI3L1 inhibitor
|
CHI3L1 inhibitor 11g is a potent, selective CHI3L1 (chitinase-3-like protein 1) inhibitor with SPR Kd of 13.76 uM. |
| PC-24717 |
CHI3L1 inhibitor G28
CHI3L1 inhibitor
|
CHI3L1 inhibitor G28 is a potent small molecule CHI3L1 binder/inhibitor with KD of 51.4 uM. |
| PC-23541 |
G721-0282
CHI3L1 inhibitor
|
G721-0282 is a specific small molecule inhibitor of chitinase-3 like-protein-1 (CHI3L1, YKL-40), inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway. |
