| Cat. No. |
Product Name |
Information |
| PC-23372 |
ACHM-025
DNA alkylating agent
|
ACHM-025 is a third generation AKR1C3-activated prodrug, selectively activates by AKR1C3 in the presence of NADPH to form the nitrogen mustard DNA alkylating agent. |
| PC-21025 |
CDEAH
Alkylating agent
|
CDEAH is a monofunctional alkylating agent that selectively kills PARP1- and xeroderma pigmentosum A-deficient cells. |
| PC-49195 |
NSC373981
CARD11 G4 stabilizer
|
NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells. |
| PC-49169 |
QBS10072S
Alkylating agent
|
QBS10072S is a novel dual-function, BBB permeable chemotherapeutic agent with alkylating moiety and a selective large neutral amino acid transporter 1 (LAT1, SLC7A5) substrate, shows excellent BBB penetration and promising efficacy in vitro (U251 cell IC50=12 uM) and in vivo against glioblastoma (GBM). |
| PC-38759 |
AST-3424 (S-isomer)
DNA alkylating agent
|
OBI-3424 S-isomer (TH-3424, OBI 3424) is a highly potent DNA alkylating prodrug that is converted by AKR1C3 to a potent DNA-alkylating agent. |
| PC-35531 |
OBI-3424
DNA alkylating agent
|
OBI-3424 (AST-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent. |
| PC-43488 |
Mitomycin C
DNA alkylating agent
|
Mitomycin C (Ametycine) is a chemotherapeutic antibiotic that acts as a double-stranded DNA alkylating agent. |
| PC-63051 |
Dicycloplatin
DNA alkylating agent
|
Dicycloplatin (DCP) is a novel platinum analog that demonstrates significant antitumor activity against a variety of human cancer cell lines with IC50 of 25-30 nM. |
| PC-62506 |
CM03
G-quadruplex binder
|
CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM). |
| PC-61486 |
Glufosfamide
Alkylating agent
|
A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters. |
| PC-61356 |
Alchemix
Alkylating agent, Topo inhibitor
|
Alchemix (ZP281M) is a dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer. |
| PC-60562 |
Melflufen hydrochloride
Alkylating agent
|
Melflufen hydrochloride (Melphalan flufenamide, J1) is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo. |
