| Cat. No. |
Product Name |
Information |
| PC-45364 |
Satraplatin
DNA alkylating agent
|
Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis. |
| PC-45240 |
Ifosfamide
DNA alkylating agent
|
Ifosfamide is a nitrogen mustard alkylating agent and DNA alkylator with broad anticancer activity against a wide range of tumors. |
| PC-45909 |
Trabectedin
Alkylating agent
|
Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata that shows remarkably anticancer activity in a variety of in vitro and in vivo systems. |
| PC-45216 |
Cisplatin
DNA alkylating agent
|
Cisplatin is a chemotherapy agent that interferes with DNA replication and kills cancer cells. |
| PC-45215 |
Carboplatin
DNA alkylating agent
|
Carboplatin (NSC 241240) is a chemotherapy agent that interferes with DNA replication and kills cancer cells. |
| PC-45363 |
Melphalan
DNA alkylating agent
|
Melphalan is a chemotherapy agent that acts through alkylation of the DNA nucleotide guanine, and causes linkages between strands of DNA. |
| PC-27661 |
Ecteinascidin 770
Transcription inhibitor
|
Ecteinascidin 770 (Et-770) is a a stabilized derivative of Trabectedin with anticaner activity, kills U373MG glioblastoma cells in culture with IC50 of 4.83 nM in MTT assays. |
| PC-25508 |
CP-506 mesylate
DNA alkylating agent, Hypoxia-activated prodrug
|
CP-506 mesylate is a DNA alkylating hypoxia-activated prodrug (HAP), shows selective antitumor effects for hypoxic tumor cells and causally related to tumor oxygenation. |
| PC-25507 |
CP-506
DNA alkylating agent, Hypoxia-activated prodrug
|
CP-506 is a DNA alkylating hypoxia-activated prodrug (HAP), shows selective antitumor effects for hypoxic tumor cells and causally related to tumor oxygenation. |
| PC-24467 |
BMVC-8C3O
G4 ligand, M.tb Pks13 inhibitor
|
BMVC-8C3O is a novel small molecule inhibitor of Mycobacterium tuberculosis Pks13 with IC50 of 6.94 uM and SPR KD of 18.9 uM, also is a small molecule G-quadruplex (G4) ligand. |
| PC-23371 |
PR-104
DNA alkylating agent
|
PR-104 is a hypoxia-activated DNA cross-linking agent and phosphate ester of the nitrogen mustard prodrug PR-104A, shows selective DNA cross-linking selective cytotoxicity under hypoxia in cancer cells. |
| PC-22218 |
SJG-136
DNA cross-linking agent
|
SJG-136 (SG2000, NSC 694501) is a potent DNA cross-linking agent and DNA-binding payload with XL50 (50% cross-linking of pBR322 DNA) of 45 nM, shows potent antitumor activity. |
