| Cat. No. |
Product Name |
Information |
| PC-22747 |
ZJCK-6-46
DYRK1A inhibitor
|
ZJCK-6-46 is a potent, selective, and orally available dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor with IC50 of 0.68 nM. |
| PC-22435 |
GNF4877
DYRK1A/GSK3β inhibitor
|
GNF4877 is a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) with IC50 of 6 nM and 16 nM, respectively, has a synergistic effect enhancing β-cell proliferation. |
| PC-21506 |
Leucettinib-21
CLK/DYRK inhibitor
|
Leucettinib-21 is a potent, selective DYRKs and CLKs kinases with IC50 of 2.4, 6.7, 12, 33, and 5 nM for DYRK1A, DYRK1B, CLK1, CLK2, and CLK4, respectively. |
| PC-49263 |
AZ Dyrk1B 33
DYRK inhibitor
|
AZ Dyrk1B 33 is a potent dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with IC50 of 16.8/39/254/430 nM for DYRK1A/1B/2/3, respectively, does not inhibit DYRK4 (IC50>30 uM). |
| PC-38751 |
YK-2-69
DYRK2 inhibitor
|
YK-2-69 is a potent, hilghly selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with IC50 value of 9 nM, shows weak inhibition against DYRK1B (IC50=542 nM) and no activity against DYRK1A/3/4 (IC50>1,000 nM). |
| PC-38492 |
DYRK2 inhibitor C17
DYRK2 inhibitor
|
DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM). |
| PC-73293 |
BT173
HIPK2 inhibitor
|
BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway. |
| PC-72581 |
CaNDY
CLK/DYRK inhibitor
|
CaNDY is a highly potent rectifier of the aberrant splicing, potently inhibits DYRK1A, DYRK1B, CLK1/CLK2 with IC50 of 21.6/68.3/116 nM in in vitro kinase assays. |
| PC-72351 |
GNF2133
DYRK1A inhibitor
|
GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β. |
| PC-43249 |
Mirk-IN-1
DYRK1A/1B inhibitor
|
Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM. |
| PC-42939 |
AZ191
DYRK1B inhibitor
|
AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM). |
| PC-61025 |
Leucettine L41
CLK/DYRK inhibitor
|
Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively. |
