| Cat. No. |
Product Name |
Information |
| PC-73294 |
MU1787
HIPK inhibitor
|
MU1787 is a potent, highly selective Homeodomain-interacting protein kinases (HIPKs) inhibitor with IC50 of 285/123/283 nM for HIPK1/2/3, repectively. |
| PC-73293 |
BT173
HIPK2 inhibitor
|
BT173 (BT-173) is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway. |
| PC-73292 |
JWD-065
HIPK2 inhibitor
|
JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM. |
| PC-73291 |
CVM-6-139-1
HIPK2 inhibitor
|
CVM-6-139-1 (HIPK2 inhibitor A64) is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 401 nM. |
| PC-72581 |
CaNDY
CLK/DYRK inhibitor
|
CaNDY is a highly potent rectifier of the aberrant splicing, potently inhibits DYRK1A, DYRK1B, CLK1/CLK2 with IC50 of 21.6/68.3/116 nM in in vitro kinase assays. |
| PC-72351 |
GNF2133
DYRK1A inhibitor
|
GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β. |
| PC-43249 |
Mirk-IN-1
DYRK1A/1B inhibitor
|
Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM. |
| PC-42939 |
AZ191
DYRK1B inhibitor
|
AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM). |
| PC-61025 |
Leucettine L41
CLK/DYRK inhibitor
|
Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively. |
| PC-42167 |
TBID
HIPK2 inhibitor
|
tBID is a potent, selective and cell permeable homeodomain-interacting protein kinase 2 (HIPK2) inhibitor with IC50 of 0.33 uM. |
| PC-27003 |
DYRK inhibitor FC-3
DYRK1A inhibitor
|
DYRK inhibitor FC-3 is a potent, selective, reversible, ATP-competitive inhibitor of Dual-specificity tyrosine-regulated kinases (DYRKs) with IC50 of 53 nM (DYRK1A). |
| PC-27002 |
DYRK inhibitor FC-2
DYRK1A inhibitor
|
DYRK inhibitor FC-2 is a potent, selective, reversible, ATP-competitive inhibitor of Dual-specificity tyrosine-regulated kinases (DYRKs) with IC50 of 19 nM (DYRK1A). |
