| Cat. No. |
Product Name |
Information |
| PC-72351 |
GNF2133
DYRK1A inhibitor
|
GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β. |
| PC-43249 |
Mirk-IN-1
DYRK1A/1B inhibitor
|
Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM. |
| PC-42939 |
AZ191
DYRK1B inhibitor
|
AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM). |
| PC-61025 |
Leucettine L41
CLK/DYRK inhibitor
|
Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively. |
| PC-42167 |
TBID
HIPK2 inhibitor
|
tBID is a potent, selective and cell permeable homeodomain-interacting protein kinase 2 (HIPK2) inhibitor with IC50 of 0.33 uM. |
| PC-26800 |
ZJCK-6-72
DYRK1A inhibitor
|
ZJCK-6-72 is a highly potent, orally bioavailable, blood-brain barrier (BBB) permeable DYRK1A inhibitor with IC50 of 8.64 nM. |
| PC-26298 |
ZRMQ-22
DYRK1A inhibitor
|
ZRMQ-22 is a highly potent DYRK1A inhibitor with IC50 of 0.35 nM, concentration-dependently inhibits nitric oxide (NO) production in LPS-stimulated BV2 cells with IC50 of 1 uM. |
| PC-26150 |
TSL2109
DYRK2 inhibitor
|
TSL2109 is a potent, selective, orally active Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) inhibitor with IC50 of 22 nM. |
| PC-25697 |
MU135
HIPK inhibitor
|
MU135 is a potent, highly selective Homeodomain-interacting protein kinases (HIPKs) inhibitor with IC50 of 248/119/476 nM for HIPK1/HIPK12/HIPK13, repectively. |
| PC-25696 |
XRF-1021
HIPK2 inhibitor
|
XRF-1021 is a potent inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with IC50 of 0.18 uM, suppresses HIPK2 and blocks TGF-β/Smad3, NF-κB, Wnt/β-catenin, and Notch signaling. |
| PC-25353 |
DYRK1A/1B inhibitor 8h
DYRK1A/DYRK1B inhibitor
|
DYRK1A/1B inhibitor 8h is a potent, selective DYRK1A/DYRK1B inhibitor with IC50 of 5 nM and 3 nM respectively. |
| PC-25352 |
KS-40070
DYRK1B inhibitor
|
KS-40070 is a potent, selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with IC50 of 18 nM, with no inhibition on human DYRK2 (IC50>10 uM). |
