| Cat. No. |
Product Name |
Information |
| PC-26690 |
AZ137
HIPK4 inhibitor
|
AZ137 is a potent and selective Homeodomain-interacting protein kinase 4 (HIPK4) inhibitor with biochemical IC50 of 11 nM and cellular EC50 of 76 nM. |
| PC-26150 |
TSL2109
DYRK2 inhibitor
|
TSL2109 is a potent, selective, orally active Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) inhibitor with IC50 of 22 nM. |
| PC-25352 |
KS-40070
DYRK1B inhibitor
|
KS-40070 is a potent, selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with IC50 of 18 nM, with no inhibition on human DYRK2 (IC50>10 uM). |
| PC-23472 |
GSK626616
DYRK inhibitor
|
GSK626616 is a potent, orally bioavailable inhibitor of DYRK3 with IC50 of 0.7 nM, inhibits other members of the DYRK family, e.g., DYRK1A and DYRK2, with similar potency. |
| PC-23234 |
DYR219
DYRK1 inhibitor
|
DYR219 is a potent, selective, type 1 ATP-competitive inhibitor of DYRK1 with IC50 of 34 nM (DYRK1A) and 29 nM (DYRK1B), induces degradation of Dyrk1a protein. |
| PC-22747 |
ZJCK-6-46
DYRK1A inhibitor
|
ZJCK-6-46 is a potent, selective, and orally available dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor with IC50 of 0.68 nM. |
| PC-22601 |
DYC-1
DYRK2/HDAC8 inhibitor
|
DYC-1 is a potent, dual-target DYRK2/HDAC8 inhibitor with IC50 of 5.27 and 8.06 nM respectively, exhibits potent antiproliferative and antitumor activity against liver cancer. |
| PC-22435 |
GNF4877
DYRK1A/GSK3β inhibitor
|
GNF4877 is a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) with IC50 of 6 nM and 16 nM, respectively, has a synergistic effect enhancing β-cell proliferation. |
| PC-21506 |
Leucettinib-21
CLK/DYRK inhibitor
|
Leucettinib-21 is a potent, selective DYRKs and CLKs kinases with IC50 of 2.4, 6.7, 12, 33, and 5 nM for DYRK1A, DYRK1B, CLK1, CLK2, and CLK4, respectively. |
| PC-49263 |
AZ Dyrk1B 33
DYRK inhibitor
|
AZ Dyrk1B 33 is a potent dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with IC50 of 16.8/39/254/430 nM for DYRK1A/1B/2/3, respectively, does not inhibit DYRK4 (IC50>30 uM). |
| PC-38751 |
YK-2-69
DYRK2 inhibitor
|
YK-2-69 is a potent, hilghly selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with IC50 value of 9 nM, shows weak inhibition against DYRK1B (IC50=542 nM) and no activity against DYRK1A/3/4 (IC50>1,000 nM). |
| PC-38492 |
DYRK2 inhibitor C17
DYRK2 inhibitor
|
DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM). |
