| Cat. No. |
Product Name |
Information |
| PC-22435 |
GNF4877
DYRK1A/GSK3β inhibitor
|
GNF4877 is a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) with IC50 of 6 nM and 16 nM, respectively, has a synergistic effect enhancing β-cell proliferation. |
| PC-38751 |
YK-2-69
DYRK2 inhibitor
|
YK-2-69 is a potent, hilghly selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with IC50 value of 9 nM, shows weak inhibition against DYRK1B (IC50=542 nM) and no activity against DYRK1A/3/4 (IC50>1,000 nM). |
| PC-73293 |
BT173
HIPK2 inhibitor
|
BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway. |
| PC-72351 |
GNF2133
DYRK1A inhibitor
|
GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β. |
| PC-42939 |
AZ191
DYRK1B inhibitor
|
AZ191 is a potent, selective DYRK1B inhibitor with IC50 of 17 nM, displays 10-fold selectivity over DYRK1A and no activity against DYRK2 (IC50=1890 nM). |
| PC-42167 |
TBID
HIPK2 inhibitor
|
tBID is a potent, selective and cell permeable homeodomain-interacting protein kinase 2 (HIPK2) inhibitor with IC50 of 0.33 uM. |
| PC-22437 |
proINDY
DYRK1A inhibitor
|
proINDY is the acetylated derivative prodrug of INDY, which is a potent, selective and ATP-competitive inhibitor of Dyrk1A, effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression. |
| PC-22436 |
INDY
DYRK1A inhibitor
|
INDY is a potent, selective and ATP-competitive inhibitor of Dyrk1A withIC50 and Ki values of 0.24 and 0.18 μM, respectively. |
| PC-21660 |
Y020-3945
DYRK1A inhibitor
|
Y020-3945 is a selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor with IC50 of 0.53 uM. |
| PC-21506 |
Leucettinib-21
CLK/DYRK inhibitor
|
Leucettinib-21 is a potent, selective DYRKs and CLKs kinases with IC50 of 2.4, 6.7, 12, 33, and 5 nM for DYRK1A, DYRK1B, CLK1, CLK2, and CLK4, respectively. |
| PC-21496 |
EHT 1610
DYRK1A inhibitor
|
EHT 1610 is a potent inhibitor of DYRKs family kinases with IC50s of 0.36 nM (DYRK1A), 0.59 nM (DYRK1B), respectively. |
| PC-21495 |
FC162
DYRK1A inhibitor
|
FC162 is a potent inhibitor of DYRK1A with IC50 of 11, 18, and 68 nM, against DYRK1A, CLK1, and GSK3, respectively. |
