| Cat. No. |
Product Name |
Information |
| PC-28373 |
Mazdutide TFA
GCGR/GLP-1 agonist
|
Mazdutide TFA (IBI362, LY3305677) is a synthetic peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor (GCGR), binds human and mouse GCGR (Ki=17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki=28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50=5.2 nM). |
| PC-28372 |
Mazdutide
GCGR/GLP-1 agonist
|
Mazdutide (IBI362, LY3305677) is a synthetic peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor (GCGR), binds human and mouse GCGR (Ki=17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki=28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50=5.2 nM). |
| PC-28066 |
PF-07976016
GIPR antagonist
|
PF-07976016 is a potent, orally active glucose-dependent insulinotropic polypeptide receptor (GIPR) antagonist with IC50 of 4.1 nM, shows competitively binding to GIPR and blocking the increase in Gαs-mediated cAMP production induced by GIP agonists. |
| PC-27466 |
Gimaglipron
GLP-1 agonist
|
Gimaglipron (VCT220) is a potent, selective, nonpeptide, orally available glucagon-like peptide-1 receptor agonist (GLP-1RA). |
| PC-25559 |
YN1548
GLP-1R agonist
|
YN1548 is a potent, highly selective agonist of human glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 4.59, 24.28, and 2.20 nM in CHO cells expressing low, mid, and high human GLP-1 receptor levels in a dose-dependent manner, respectively. |
| PC-24418 |
DD202-114
GLP-1R agonist
|
DD202-114 (Conveglipron, HDM1002) is a potent and selective glucagon-like peptide-1 receptor (GLP-1R) agonist with EC50 of 0.03 nM in cAMP assay in HEK293 cells expressing hGLP-1R. |
| PC-24125 |
ECC5004
GLP-1R agonist
|
Elecoglipron (ECC5004/AZD5004) is a novel small-molecule GLP-1 receptor (GLP-1R) agonist, binds to the human GLP-1R with IC50 of 2.4 nM, displays a full agonist profile with a potency of 2.1 nM. |
| PC-23667 |
Aleniglipron
GLP-1R agonist
|
Aleniglipron (GSBR-1290) is a fully biased, orally available, potent GLP-1R agonist with binding Ki of <10 nM and cAMP EC50 of <0.1 nM. |
| PC-23479 |
Liraglutide
GLP-1 agonist
|
Liraglutide (NN2211) is a long-acting GLP-1 analogue, glucagon-like peptide-1 (GLP-1) receptor agonist, induces lasting and reversible weight loss. |
| PC-22331 |
Lotiglipron
GLP-1R agonist
|
Lotiglipron (PF-07081532) is an oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist, shows potential for type 2 diabetes (T2D) and/or obesity. |
| PC-21204 |
Teduglutide
GLP-2 analogue, Nur77 activator
|
Teduglutide (ALX-0600, h[Gly(2)]GLP-2) is a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models, activates the expression of nuclear receptor subfamily 4 group a member 1 (NR4A1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. |
| PC-21069 |
Retatrutide
GIP/GLP-1/GCGR agonist
|
Retatrutide (LY3437943) is a potent, triple agonist peptide of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 5.79 nM, 0.064 nM and 0.775 nM in cAMP assays. |
