| Cat. No. |
Product Name |
Information |
| PC-25559 |
YN1548
GLP-1R agonist
|
YN1548 is a potent, highly selective agonist of human glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 4.59, 24.28, and 2.20 nM in CHO cells expressing low, mid, and high human GLP-1 receptor levels in a dose-dependent manner, respectively. |
| PC-24418 |
DD202-114
GLP-1R agonist
|
DD202-114 (Conveglipron, HDM1002) is a potent and selective glucagon-like peptide-1 receptor (GLP-1R) agonist with EC50 of 0.03 nM in cAMP assay in HEK293 cells expressing hGLP-1R. |
| PC-24125 |
ECC5004
GLP-1R agonist
|
Elecoglipron (ECC5004/AZD5004) is a novel small-molecule GLP-1 receptor (GLP-1R) agonist, binds to the human GLP-1R with IC50 of 2.4 nM, displays a full agonist profile with a potency of 2.1 nM. |
| PC-23667 |
Aleniglipron
GLP-1R agonist
|
Aleniglipron (GSBR-1290) is a fully biased, orally available, potent GLP-1R agonist with binding Ki of <10 nM and cAMP EC50 of <0.1 nM. |
| PC-23479 |
Liraglutide
GLP-1 agonist
|
Liraglutide (NN2211) is a long-acting GLP-1 analogue, glucagon-like peptide-1 (GLP-1) receptor agonist, induces lasting and reversible weight loss. |
| PC-22331 |
Lotiglipron
GLP-1R agonist
|
Lotiglipron (PF-07081532) is an oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist, shows potential for type 2 diabetes (T2D) and/or obesity. |
| PC-21204 |
Teduglutide
GLP-2 analogue, Nur77 activator
|
Teduglutide (ALX-0600, h[Gly(2)]GLP-2) is a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models, activates the expression of nuclear receptor subfamily 4 group a member 1 (NR4A1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. |
| PC-21069 |
Retatrutide
GIP/GLP-1/GCGR agonist
|
Retatrutide (LY3437943) is a potent, triple agonist peptide of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 5.79 nM, 0.064 nM and 0.775 nM in cAMP assays. |
| PC-73177 |
Semaglutide
GLP-1 agonist
|
Semaglutide (NN 9535) is a glucagon-like peptide-1 (GLP-1) peptide agonist with binding IC50 of 0.38 nM, increases insulin secretion and sugar metabolism. |
| PC-72854 |
(S)-V-0219
GLP-1R PAM
|
(S)-(+)-V-0219 is an orally acitve, small molecule positive allosteric modulator (PAM) of GLP-1R. |
| PC-72853 |
V-0219
GLP-1R PAM
|
V-0219 is a small molecule positive allosteric modulator (PAM) of GLP-1R with Emax of 60% in the cAMP assay. |
| PC-72629 |
Tirzepatide
Dual GIP/GLP-1 agonist
|
Tirzepatide (LY3298176) is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, binds both receptor with high affinity (GIPR Ki=0.135; GLP-1R Ki=4.23 nM). |
