| Cat. No. |
Product Name |
Information |
| PC-73177 |
Semaglutide
GLP-1 agonist
|
Semaglutide (NN 9535) is a glucagon-like peptide-1 (GLP-1) peptide agonist with binding IC50 of 0.38 nM, increases insulin secretion and sugar metabolism. |
| PC-72854 |
(S)-(+)-V-0219
GLP-1R PAM
|
(S)-(+)-V-0219 is an orally acitve, small molecule positive allosteric modulator (PAM) of GLP-1R. |
| PC-72629 |
Tirzepatide
Dual GIP/GLP-1 agonist
|
Tirzepatide (LY3298176) is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, binds both receptor with high affinity (GIPR Ki=0.135; GLP-1R Ki=4.23 nM). |
| PC-72605 |
Cotadutide
Dual GLP-1/glucagon receptor agonist
|
Cotadutide (MEDI-0382, MEDI0382) is a potent dual GLP-1/glucagon receptor peptide agonist with EC50 values of 6.9 pM and 10.2 pM, respectively. |
| PC-72211 |
LY3502970
GLP-1 agonist
|
LY3502970 (Orforglipron, OWL-833) is a potent, selective, orally active non-peptide agonist of glucagon-like peptide-1 (GLP-1) receptor. |
| PC-43538 |
Exenatide
GLP-1 agonist
|
Exenatide (Exendin-4) is a 39-aa peptide, highly potent, long-acting glucagon-like peptide-1 receptor (GLP-1) agonist with IC50 of 3.22 nM. |
| PC-70024 |
PF-06372222
|
A potent glucagon receptor (GCGR) negative allosteric modulator.. |
| PC-70023 |
NNC-0640
|
NNC-0640 (NNC 0640, NNC0640) is a potent, selective glucagon receptor (GCGR) negative allosteric modulator with IC50 of 69.2 nM. |
| PC-45831 |
MK-0893
Glucagon receptor antagonist
|
A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM). |
| PC-45758 |
GCGR-IN-17
|
PF06291874 (GCGR-IN-17) is a highly potent glucagon receptor antagonist with Ki of 14 nM for hGCGR. |
| PC-21204 |
Teduglutide
GLP-2 analogue
|
Teduglutide (ALX-0600, h[Gly(2)]GLP-2) is a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models. |
| PC-21069 |
Retatrutide
GIP/GLP-1/GCGR agonist
|
Retatrutide (LY3437943) is a potent, triple agonist peptide of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 5.79 nM, 0.064 nM and 0.775 nM in cAMP assays. |
