| Cat. No. |
Product Name |
Information |
| PC-61961 |
IT-901
c-Rel/NF-κB inhibitor
|
IT-901 is a novel potent, small molecule inhibitor of NF-κB subunit c-Rel, inhibits DNA binding of c-Rel and NF-κB activity with IC50 of 3 uM. |
| PC-70271 |
IT-603
c-Rel/NF-κB inhibitor
|
IT-603 is a small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays. |
| PC-60551 |
NDMC101
Osteoclastogenesis inhibitor
|
NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo. |
| PC-60550 |
ABD328
RANKL inhibitor
|
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo. |
| PC-42493 |
BAY 11-7085
IκB inhibitor
|
BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation. |
| PC-45134 |
Iguratimod
COX-2 inhibitor, MIF inhibitor
|
Iguratimod (TT-614) is an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM. |
| PC-45545 |
Lipoic acid
|
Lipoic acidis a multifunction antioxidant that has growth promoting, anti-inflammatory, antioxidative, immunostimulatory, and hypocholesterolemic properties. |
| PC-22689 |
ZM600
HSCs activation inhibitor
|
ZM600 is a novel antihepatic fibrosis compound that shows significant inhibitory effect on the activation of hepatic stellate cells (HSCs), specifically inhibits the activation of NF-κB, PI-3K/AKT, and TGF-β/Smads signaling pathways. |
| PC-21743 |
JSH-23
NF-κB inhibitor
|
JSH-23 is a small molecule NF-κB inhibitor, inhibits NF-κB transcriptional activity with IC50 of 7.1 uM in LPS-stimulated macrophages RAW 264.7. |
| PC-21657 |
CSB-0914
NF-κB inhibitor
|
CSB-0914 is a small molecule NF-κB inhibitor that stably binds to NF-κB-p50 subunit, exhibits significant efficacy in reducing basophil activation assay induced by FcεRI receptors with IC50 of 98.4 nM. |
| PC-21362 |
AE-848
NF-κB modualator
|
AE-848 is a small molecule modulator of NF-κB and PI3K/AKT/mTOR signaling pathways, shows potent in vitro and in vivo anti-myeloma activity. |
| PC-21026 |
AS2676293
RANKL inhibitor
|
AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM. |
