| Cat. No. |
Product Name |
Information |
| PC-27798 |
(+)-Magnoflorine chloride
NF-κB/MAPK inhibitor
|
Magnoflorine chloride ((+)-Magnoflorine) is a dietary alkaloid from Alpinia oxyphylla fruit within anxiolytics, anti-cancer, and anti-inflammatory properties, inhibits the activation of NF-κB and MAPK signaling pathways. |
| PC-27797 |
(+)-Magnoflorine
NF-κB/MAPK inhibitor
|
Magnoflorine ((+)-Magnoflorine) is a dietary alkaloid from Alpinia oxyphylla fruit within anxiolytics, anti-cancer, and anti-inflammatory properties, inhibits the activation of NF-κB and MAPK signaling pathways. |
| PC-27553 |
DYT-40
AEG-1 inhibitor, NF-κB inhibitor
|
DYT-40 is a small molecule inhibitor of Astrocyte elevated gene-1 (AEG-1) expression and NF-κB nuclear translocation, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways. |
| PC-25983 |
CARD9 inhibitor Compound 6
CARD9 inhibitor
|
CARD9 inhibitor Compound 6 is a potent, specific CARD9 inhibitor with SPR Kd of 120 nM (human CARD9), and IC50 of 0.33 uM in TR-FRET assays, blocks CARD9-dependent NF-κB activation and cytokine release. |
| PC-25329 |
RANKL inhibitor T8
RANKL inhibitor
|
RANKL inhibitor T8 is a nonpeptidic small molecular inhibitor targeting RANKL and RANK protein interaction, directly binds to RANKL with KD of 6.3 uM. |
| PC-25328 |
RANKL inhibitor 34
RANKL inhibitor
|
RANKL inhibitor 34 is a potent and selective RANKL/RANK inhibitor, displays high affinity for RANKL with SPR Kd of 614 nM, effectively inhibits RANKL-induced osteoclastogenesis and bone resorption. |
| PC-24857 |
Ro106-9920
NF-κB inhibitor
|
Ro106-9920 is a specific small molecule inhibitor of NF-kappa B-dependent cytokine expression with IC50 of <1 uM in human PBMSc, selectively inhibits IkappaB(alpha)(ee) ubiquitination with with iC50 of 2.3 uM. |
| PC-24780 |
F1929-1458
NFKB1 agonist
|
F1929-1458 is a small molecule NFKB1 (Nuclear factor κB subunit 1, NF-κB subunit 1) agonist, activates NF-κB signaling pathway, promotes anti-tumor immunity by remodeling the TME and activating DCs. |
| PC-24658 |
SM-7368
NF-κB inhibitor
|
SM-7368 is a small molecule NF-kB inhibitor, inhibits TNF-alpha-induced MMP-9 upregulation, strongly inhibits TNF-alpha-induced NF-kappaB activity but not AP-1 activity. |
| PC-24073 |
RelB inhibitor RS47
RelB inhibitor
|
RelB inhibitor RS47 is a potent and specific small molecule targeting RelB (MST, binding Kd=1.1 uM) to inhibit non-canonical NF-κB signaling pathway, with no inhibitory effect on canonical NF-κB signaling pathway. |
| PC-23849 |
SMEPPI
NF-κB p65 inhibitor
|
SMEPPI is a small molecule inhibitor of expression and activation of NF-κB p65, induces NF-κB p65 proteasomal degradation and has anti-diabetic and anti-inflammatory activities. |
| PC-22689 |
ZM600
HSCs activation inhibitor
|
ZM600 is a novel antihepatic fibrosis compound that shows significant inhibitory effect on the activation of hepatic stellate cells (HSCs), specifically inhibits the activation of NF-κB, PI-3K/AKT, and TGF-β/Smads signaling pathways. |
