| Cat. No. |
Product Name |
Information |
| PC-70271 |
IT-603
c-Rel/NF-κB inhibitor
|
IT-603 is a small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays. |
| PC-60551 |
NDMC101
Osteoclastogenesis inhibitor
|
NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo. |
| PC-60550 |
ABD328
RANKL inhibitor
|
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo. |
| PC-42493 |
BAY 11-7085
IκB inhibitor
|
BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation. |
| PC-45134 |
Iguratimod
COX-2 inhibitor, MIF inhibitor
|
Iguratimod (TT-614) is an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM. |
| PC-45545 |
Lipoic acid
|
Lipoic acidis a multifunction antioxidant that has growth promoting, anti-inflammatory, antioxidative, immunostimulatory, and hypocholesterolemic properties. |
| PC-25329 |
RANKL inhibitor T8
RANKL inhibitor
|
RANKL inhibitor T8 is a nonpeptidic small molecular inhibitor targeting RANKL and RANK protein interaction, directly binds to RANKL with KD of 6.3 uM. |
| PC-25328 |
RANKL inhibitor 34
RANKL inhibitor
|
RANKL inhibitor 34 is a potent and selective RANKL/RANK inhibitor, displays high affinity for RANKL with SPR Kd of 614 nM, effectively inhibits RANKL-induced osteoclastogenesis and bone resorption. |
| PC-24857 |
Ro106-9920
NF-κB inhibitor
|
Ro106-9920 is a specific small molecule inhibitor of NF-kappa B-dependent cytokine expression with IC50 of <1 uM in human PBMSc, selectively inhibits IkappaB(alpha)(ee) ubiquitination with with iC50 of 2.3 uM. |
| PC-24780 |
F1929-1458
NFKB1 agonist
|
F1929-1458 is a small molecule NFKB1 (Nuclear factor κB subunit 1, NF-κB subunit 1) agonist, activates NF-κB signaling pathway, promotes anti-tumor immunity by remodeling the TME and activating DCs. |
| PC-24658 |
SM-7368
NF-κB inhibitor
|
SM-7368 is a small molecule NF-kB inhibitor, inhibits TNF-alpha-induced MMP-9 upregulation, strongly inhibits TNF-alpha-induced NF-kappaB activity but not AP-1 activity. |
| PC-24073 |
RelB inhibitor RS47
RelB inhibitor
|
RelB inhibitor RS47 is a potent and specific small molecule targeting RelB (MST, binding Kd=1.1 uM) to inhibit non-canonical NF-κB signaling pathway, with no inhibitory effect on canonical NF-κB signaling pathway. |
