| Cat. No. |
Product Name |
Information |
| PC-62804 |
SEMBL
NF-κB inhibitor
|
SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65. |
| PC-62417 |
Helenalin
p65 inhibitor
|
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway. |
| PC-62155 |
Withaferin A
NF-κB inhibitor
|
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism. |
| PC-62114 |
Isoquercetin
NF-κB modulator
|
Isoquercetin is a flavonoid and 3-O-glucoside of quercetin that displays selective cytotoxicity to cancer cells, primarily by inducing apoptosis and cell cycle arrest, regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. |
| PC-61961 |
IT-901
c-Rel/NF-κB inhibitor
|
IT-901 is a novel potent, small molecule inhibitor of NF-κB subunit c-Rel, inhibits DNA binding of c-Rel and NF-κB activity with IC50 of 3 uM. |
| PC-70271 |
IT-603
c-Rel/NF-κB inhibitor
|
IT-603 is a small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays. |
| PC-60551 |
NDMC101
Osteoclastogenesis inhibitor
|
NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo. |
| PC-60550 |
ABD328
RANKL inhibitor
|
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo. |
| PC-42493 |
BAY 11-7085
IκB inhibitor
|
BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation. |
| PC-45134 |
Iguratimod
COX-2 inhibitor, MIF inhibitor
|
Iguratimod (TT-614) is an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM. |
| PC-45545 |
Lipoic acid
|
Lipoic acidis a multifunction antioxidant that has growth promoting, anti-inflammatory, antioxidative, immunostimulatory, and hypocholesterolemic properties. |
| PC-27799 |
Magnoflorine iodide
NF-κB/MAPK inhibitor
|
Magnoflorine iodide ((+)-Magnoflorine iodide) is a dietary alkaloid from Alpinia oxyphylla fruit within anxiolytics, anti-cancer, and anti-inflammatory properties, inhibits the activation of NF-κB and MAPK signaling pathways. |
