| Cat. No. |
Product Name |
Information |
| PC-72827 |
ARUK3001185
Notum inhibitor
|
ARUK3001185 is a potent, selective, brain-penetrant inhibitor of Wnt-deactivating enzyme Notum carboxylesterase activity with IC50 of 6.7 nM in OPTS biochemical assay. |
| PC-72826 |
LP-922056
Notum inhibitor
|
LP-922056 (LP922056) is a potent Notum inhibitor with IC50 of 1.1 nM in OPTS assays. |
| PC-72825 |
Notum covalent inhibitor 2
Notum inhibitor
|
Notum covalent inhibitor 2 is a potent, covalent Notum inhibitor with IC50 of 12 nM in OPTS assays, more poent than Notum covalent inhibitor 1. |
| PC-72824 |
Notum covalent inhibitor 1
Notum inhibitor
|
Notum covalent inhibitor 1 is a potent, covalent Notum inhibitor with IC50 of 93 nM in OPTS assays. |
| PC-72823 |
Notum inhibitor 23dd
Notum inhibitor
|
Notum inhibitor 23dd is a potent, brain-penetrant and orally active inhibitor of Notum carboxylesterase activity with IC50 of 18 nM. |
| PC-72822 |
Notum inhibitor 4d
Notum inhibitor
|
Notum inhibitor 4d is a highly potent inhibitor of Notum with IC50 of <10 nM, restores Wnt/β-catenin signaling in cell-based models. |
| PC-35279 |
ABC99
Notum inhibitor
|
ABC99 (NOTUM inhibitor ABC99) is a potent, selective inhibitor of the Wnt-deacylating enzyme serine hydrolase NOTUM with IC50 of 13 nM, shows excellent selectivity across the serine hydrolase family. |
| PC-49794 |
LP-914822
NOTUM inhibitor
|
LP-914822 (LP914822) is a potent, selective and orally-active NOTUM with IC50 of 2 nM for human, mouse and rat Notum. |
| PC-49793 |
LP-935001
NOTUM inhibitor
|
LP-935001 (LP935001) is a potent, selective and orally-active NOTUM with enzyme IC50 of 0.4 nM for both of human and mouse Notum. |
