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Cat. No. Product Name Information
PC-72880

PKUMDL-WQ-2201

PHGDH inhibitor

PKUMDL-WQ-2201 is a potent, selective, allosteric inhibitor of PHGDH, binds to allosteric site II.
PC-72879

BI-4916

PHGDH inhibitor

BI-4916 (BI-4916) is the prodrug of BI-4924, which is a potent, selective NADH/NAD+-competitive PHGDH inhibitor with IC50 of 2 nM.
PC-72878

BI-4924

PHGDH inhibitor

BI-4924 (BI 4924) is a potent, selective NADH/NAD+-competitive PHGDH inhibitor with IC50 of 2 nM.
PC-35907

WQ-2101

PHGDH inhibitor

WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM).
PC-62265

NCT-502

PHGDH inhibitor

NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.
PC-62264

NCT-503

PHGDH inhibitor

NCT-503 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.
PC-42027

CBR-5884

PHGDH inhibitor

CBR-5884 (CBR5884) is a potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM.
PC-23184

LXH-3-71

PHGDH degrader

LXH-3-71 is a potent mlecular glue triggers degradation of 3-phosphoglycerate dehydrogenase (PHGDH), covalently binds to Cys281 of PHGDH, triggers significant and selective degradation of PHGDH both in vitro and in vivo.

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