| Cat. No. |
Product Name |
Information |
| PC-24508 |
Balinatunfib
TNFR1 inhibitor
|
Balinatunfib (SAR441566) is a potent, oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, binds to human TNF with SPR Kd of 15.1 nM. |
| PC-21382 |
SB-U015
TRAP1 inhibitor
|
SB-U015 is a MitoQ derivative and tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor. |
| PC-21380 |
SMTIN-C10
TRAP1 inhibitor
|
SMTIN-C10 is a potent, allosteric tumor necrosis factor receptor-associated protein-1 (TRAP1) inhibitor with IC50 of 1.88 uM, by conjugating TPP a C10 linker, and PU-H71. |
| PC-20658 |
Liquidambaric acid
TRAF2 inhibitor
|
Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays. |
| PC-73214 |
UCB-9260
TNF inhibitor
|
UCB-9260 is a specific, orally active compound, inhibits tumour necrosis factor (TNF) signaling by stabilising an asymmetric form of the trimer, binds to TNF with Kd of 13 nM. |
| PC-35450 |
Foslinanib
TRAP1 inhibitor
|
Foslinanib (TRX-818, CVM-1118) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1. |
| PC-22719 |
R-7050
TNFR inhibitor
|
R-7050 is a specific small molecule TNF-alpha receptor (TNFR) antagonist with EC50 of 0.63 uM for TNFα-induced ICAM-1 expression inhibition, shows greater selectivity toward TNFα. |
| PC-22074 |
TNFR1 inhibitor FKC
TNFR1 inhibitor
|
TNFR1 inhibitor FKC is an allosteric inhibitor targets TNFR1 (Tumor necrosis factor receptor 1), inhibits TNFR1 activation by altering the conformational states of the receptor dimer without blocking receptor-ligand interaction or disrupting receptor dimerization. |
