| Cat. No. |
Product Name |
Information |
| PC-28172 |
IMP7068
Wee1 inhibitor
|
Potrasertib (MP7068) is a potent and selective WEE1 inhibitor, exhibits superior WEE1/PLK1 selectivity (>435 fold), shows potent cytotoxicity against a wide range of cancer cell lines. |
| PC-27504 |
Surbinsertib
Wee1/Myt1 inhibitor
|
Surbinsertib (SGR-3515) is a potent, orally bioavailable, dual Wee1/Myt1 inhibitor. |
| PC-27502 |
Sirusertib
WEE1/PKMYT1 inhibitor
|
Sirusertib (ACR-2316) is a potent, selective dual WEE1/PKMYT1 (Myt1) inhibitor, shows potent WEE1 inhibition and robust activation of CDK1, CDK2, and PLK1, to induce potent tumor cell death. |
| PC-26487 |
XL495
PKMYT1 inhibitor
|
XL495 is a potent, selective and orally bioavailable PKMYT1 inhibitor, demonstrates dose-dependent antitumor activity, inhibits phosphorylation of CDK1 at Thr14, and induces phosphorylation of KAP1 at Ser824 in CDX tumors. |
| PC-73399 |
RP-6306
PKMYT1 inhibitor
|
RP-6306 (Lunresertib, RP6306) is a first-in-class, potent and selective, orally available inhibitor of PKMYT1 with IC50 of 2.4 nM, displays less potency (>35-fold) against EphA1-2, and EphB2-4, and Wee1. |
| PC-72320 |
Azenosertib
Wee1 inhibitor
|
Azenosertib (ZN-c3, Wee1 inhibitor ZN-c3) is a highly potent, selective Wee1 inhibitor with IC50 of 3.8 nM. |
| PC-72319 |
Wee1 Inhibitor II
Wee1 inhibitor
|
Wee1 Inhibitor II is a potent, selective, ATP-binding site-targeting inhibitor of Wee1 with IC50 of 59 nM, 590-fold selectivity over the related checkpoint kinase Chk1 (IC50=35 uM). |
| PC-72318 |
Zedoresertib
Wee1 inhibitor
|
Zedoresertib (Debio 0123) is a potent, orally available, and highly selective Wee1 kinase inhibitor with IC50 of 0.8 nM, Ki of 0.1 nM. |
| PC-35251 |
WEE1Hu inhibitor 1
WEE1Hu inhibitor
|
WEE1Hu inhibitor is a novel potent inhibitor of WEE1Hu kinase (also known as Wee1A) with IC50 of 68 nM against recombined WEE1Hu in ELISA assays. |
| PC-42770 |
Adavosertib
Wee1 inhibitor
|
Adavosertib (AZD-1775, MK-1775) is a potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM. |
| PC-26918 |
PKMYT1 inhibitor P29
PKMYT1 inhibitor
|
PKMYT1 inhibitor P29 is a potent, selective, allosteric inhibitor of PKMYT1, induces cryptic binding site and conformational change. |
| PC-26642 |
APO-50815
WEE1 inhibitor
|
APO-50815 is a potent and selective WEE1 kinase inhibitor with IC50 of 9 nM, 10-fold selective over PLK1 and does not inhibit CHK1. |
