| Cat. No. |
Product Name |
Information |
| PC-20899 |
NuP-3
MAPK13 inhibitor
|
NuP-3 is a potent, selective MAPK13 and MAPK14 inhibitor with IC50 of 7 and 14 nM, respectively. |
| PC-73415 |
Emprumapimod
p38 MAPK inhibitor
|
Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM. |
| PC-72610 |
ARRY-371797
p38α inhibitor
|
ARRY-371797 (ARRY371797) is a potent, selective, oral p38α inhibitor with IC50 of <5 nM, directly inhibits LPS-induced IL-6 production from RPMI-8226 with IC50 of 0.1 nM. |
| PC-63564 |
BMS-751324
p38α MAPK inhibitor
|
BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM. |
| PC-63284 |
AZD-7624
p38α MAPK inhibitor
|
AZD-7624 (AZD7624) is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK. |
| PC-43421 |
LY2228820 dimesylate
p38 MAPK inhibitor
|
LY2228820 dimesylate (Ralimetinib) is a potent, selective, orally available inhibitor p38 MAPK with IC50 of 5.3 and 3.2 nM for p38α and p38β, respectively. |
| PC-60627 |
RWJ 67657
|
RWJ 67657 is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively. |
| PC-60434 |
MW-150
p38α inhibitor
|
MW-150 (MW01-18-150 SRM) is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM. |
| PC-42491 |
SB 203580
|
SB 203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM. |
| PC-42564 |
Losmapimod
p38 MAPK inhibitor
|
Losmapimod (GSK-AHAB, GW856553X, SB856553) is a selective, potent, orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
| PC-42563 |
VX-702
p38 MAPK inhibitor
|
VX-702 is a potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α. |
| PC-42565 |
Pamapimod
p38α MAPK inhibitor
|
Pamapimod (Ro4402257; R1503) is a potent, selective, orally bioavailable p38α MAPK inhibitor with Kd of 0.2 nM. |
