| Cat. No. |
Product Name |
Information |
| PC-22072 |
CHF6297
p38α/β inhibitor
|
CHF6297 (CHF-6297) is a potent and selective p38α/β MAPK inhibitor with IC50 of 0.14/0.2 nM, >1,000-fold selectivity against p38γ and p38δ. |
| PC-20899 |
NuP-3
MAPK13 inhibitor
|
NuP-3 is a potent, selective MAPK13 and MAPK14 inhibitor with IC50 of 7 and 14 nM, respectively. |
| PC-49582 |
DCZ19931
Multikinase inhibitor
|
DCZ19931 is a novel multi-targeting kinase inhibitor, exhibits anti-angiogenic effects in vitro and inhibits ocular neovascularization in vivo. |
| PC-73415 |
Emprumapimod
p38 MAPK inhibitor
|
Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM. |
| PC-72610 |
ARRY-371797
p38α inhibitor
|
ARRY-371797 (ARRY-797) is a potent, selective, oral p38α inhibitor with IC50 of <5 nM, directly inhibits LPS-induced IL-6 production from RPMI-8226 with IC50 of 0.1 nM. |
| PC-63564 |
BMS-751324
p38α MAPK inhibitor
|
BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM. |
| PC-63408 |
RV1088
p38 MAPK inhibitor
|
RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM. |
| PC-63395 |
JNJ-49095397
p38 MAPK inhibitor
|
JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively. |
| PC-63284 |
AZD-7624
p38α MAPK inhibitor
|
AZD-7624 (AZD7624) is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK. |
| PC-43421 |
LY2228820 dimesylate
p38 MAPK inhibitor
|
LY2228820 dimesylate (Ralimetinib) is a potent, selective, orally available inhibitor p38 MAPK with IC50 of 5.3 and 3.2 nM for p38α and p38β, respectively. |
| PC-43250 |
p38 MAPK-IN-4
p38 MAPK inhibitor
|
p38 MAPK-IN-4 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM for p38α, inhibits LPS-induced TNFα release in THP-1 cells with IC50 of 187 nM. |
| PC-43080 |
SKF-86002
p38 MAPK inhibitor
|
SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM. |
