| Cat. No. |
Product Name |
Information |
| PC-21324 |
Atrasentan
ETA inhibitor
|
Atrasentan (ABT-627, A-147627) is a potent, selective and orally active nonpeptide endothelin A-receptor (ETA) with IC50 of 0.055 nM. |
| PC-20103 |
IRL1620
ETB receptor agonist
|
IRL1620 (IRL-1620, Sovateltide, PMZ-1620) is a potent, selective agonist for endothelin ETB receptor with Ki of 0.016 nM, highly selective over ETA receptor (Ki=1900 nM). |
| PC-20050 |
ABT-546
ETA receptor inhibitor
|
ABT-546 (A-216546) is a potent, selective, small-molecule antagonist of ETA endothelin receptor with IC50 of 0.49 nM, shows high selectivity over ETB receptor. |
| PC-43394 |
Ambrisentan
ETA receptor inhibitor
|
Ambrisentan (BSF 208075, LU 208075) is a highly selective antagonist of the endothelin-1 type A receptor (ETA) for use in the treatment of pulmonary hypertension. |
| PC-43010 |
BQ-123
ETA receptor inhibitor
|
BQ-123 (PMZ 2123) is a potent, selective, non-competitive cyclic pentapeptide ETA receptor antagonist with IC50 of 7.3 nM. |
| PC-60030 |
Aprocitentan
Endothelin receptor antagonist
|
Aprocitentan (ACT132577) is the major and pharmacologically active metabolite of Macitentan, an orally active, dual endothelin receptor antagonist with IC50s of 3.4 nM and 987 nM for ETA/ETB receptor respectively, inhibits ET-1 and ET-2-induced contractions in functional assays. |
| PC-45639 |
Ro 46-2005
Endothelin receptor antagonist
|
Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB. |
| PC-42282 |
Zibotentan
ETA receptor inhibitor
|
Zibotentan (ZD4054) is an orally active, specific Endothelin A receptor (ETA) inhibitor with Ki of 13 nM, shows anticancer effects. |
| PC-45971 |
Sitaxsentan
ETA receptor inhibitor
|
Sitaxsentan (IPI-1040, Sitaxentan) is a potent, long acting, orally active, selective ETA receptor antagonist that binds competitively to human ETA receptor with Ki of 0.43 nM, IC50 of 1.4 nM. |
| PC-42811 |
Sitaxsentan sodium
ETA receptor inhibitor
|
Sitaxsentan sodium (TBC11251, IPI 1040) is a potent, long acting, orally active, selective ETA receptor antagonist that binds competitively to human ETA receptor with Ki of 0.43 nM, IC50 of 1.4 nM. |
| PC-23409 |
Clazosentan
ETA antagonist
|
Clazosentan (Ro 61-1790) is a potent, selective endothelin A (ETA) receptor antagonist, 1000-fold selectivity for the ETA over ETB receptor on functional assays. |
| PC-22811 |
BQ3020
ETB receptor agonist
|
BQ3020 is a potent, selective endothelin receptor (ETB receptor) agonist, inhibits [125I] ET-1 binding to ETB receptor with IC50 of 0.2 nM. |
