| Cat. No. |
Product Name |
Information |
| PC-72650 |
NCATS-SM5637
mutant IDH1 inhibitor
|
NCATS-SM5637 (NSC 791985) is a potent, selective mutant IDH1 inhibitor with IC50 of 81/72 nM for IDH1 mutant R132H/R132C, respctively. |
| PC-38189 |
DS-1001b
mutant IDH1 inhibitor
|
DS-1001b (DS1001b) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants. |
| PC-38188 |
DS-1001b free base
mutant IDH1 inhibitor
|
DS-1001b free base (DS1001b, Safusidenib) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants. |
| PC-35975 |
Olutasidenib
mutant IDH1 inhibitor
|
Olutasidenib (FT-2102) is a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor with IC50 of 21.2 nM and 114 nM for IDH1 mutant R132H and R132C, respectively. |
| PC-35209 |
BRD2879
IDH1 R132H inhibitor
|
BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM. |
| PC-35208 |
mutant IDH1 inhibitor VVS
mutant IDH1 inhibitor
|
mutant IDH1 inhibitor VVS is a potent, selective c with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line. |
| PC-35207 |
SYC-435
mutant IDH1 inhibitor
|
SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C. |
| PC-35206 |
AGI-14100
mutant IDH1 inhibitor
|
AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor, inhibits cell proliferation (human cell lines transfected with IDH1 R132H) with IC50 values of 0.76 nM (HT-1080), 0.74 nM (U87-MG) and 1.75 nM (TF1). |
| PC-35173 |
IDH889
mutant IDH1 inhibitor
|
IDH889 (IDH-889) is a potent, selective, brain penetrant, orally active IDH1 R132H mutant with IC50 of 20 nM, with good overall selectivity vs the wt IDH1. |
| PC-35142 |
MRK-A
mutant IDH1 inhibitor
|
MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio. |
| PC-35141 |
HMS-101
mutant IDH1 inhibitor
|
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively). |
| PC-62686 |
ML309
IDH1 R132H inhibitor
|
ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1. |
