| Cat. No. |
Product Name |
Information |
| PC-35141 |
HMS-101
mutant IDH1 inhibitor
|
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively). |
| PC-43052 |
Mutant IDH1-IN-1
mutant IDH1 inhibitor
|
Mutant IDH1-IN-1 is a potent, mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. |
| PC-62686 |
ML309
IDH1 R132H inhibitor
|
ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1. |
| PC-62685 |
ML309 hydrochloride
IDH1 R132H inhibitor
|
ML309 hydrochloride is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM. |
| PC-60534 |
Vorasidenib
mutant IDH1/2 inhibitor
|
Vorasidenib (AG-881) is a potent, oral, brain-penetrant dual inhibitor of mIDH1 and mIDH2 with IC50 of 6 nM and 12 nM for IDH1-R132H and IDH2-R140Q, respectively. |
| PC-60292 |
BAY-1436032
mutant IDH1 inhibitor
|
BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively. |
| PC-60164 |
IDH305
mutant IDH1 inhibitor
|
IDH305 (IDH-305) is a potent, selective, brain penetrant mutant IDH1 inhibitor with IC50 of 18 and 28 nM for IDH1 R132H and IDH1 R132C. |
| PC-70088 |
GSK321
mutant IDH1 inhibitor
|
GSK321 is a highly potent, selective inhibitor of mutant IDH1 with IC50s of 4.6/3.8/2.9 nM for R132H/R132C/R132G respectively. |
| PC-45645 |
GSK864
IDH1 inhibitor
|
GSK864 is a compound structurally related to GSK321 with improved in vivo pharmacokinetic properties, inhibits IDH1 mutants R132C, R132H, and R132G with IC50 values of 8.8, 15.2 and 16.6 nM, respectively. |
| PC-45529 |
Enasidenib
IDH2 inhibitor
|
Enasidenib (AG-221, CC-90007) is an orally available, selective, potent inhibitor of mutant IDH2 with IC50s of 100-400 nM for IDH2R140Q homodimer, IDH2R172K homodimer and IDH2WT/R140Q, IDH2WT/R172K. |
| PC-45413 |
AGI-5198
mutant IDH1 inhibitor
|
AGI-5198 (IDH-C35) is a potent, selective mutant IDH1 inhibitor with IC50 of 70 nM and 160 nM for R132H-IDH1 and R132C-IDH1, respectively. |
| PC-44670 |
AGI-6780
IDH2 R140Q inhibitor
|
AGI-6780 is a potent and selective mutant IDH2 R140Q inhibitor with IC50 of 23 nM. |
