| Cat. No. |
Product Name |
Information |
| PC-42950 |
Ozanimod
S1P1/S1P5 agonist
|
Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively. |
| PC-42341 |
Icanbelimod
S1PR1 agonist
|
Icanbelimod (CBP-307) is a highly potent, next-generation highly potent sphingosine-1-phosphate receptor (S1PR) agonist with EC50 of 3.55 nM (S1PR1), specifically targets S1PR1/4/5. |
| PC-45386 |
Cenerimod
S1P1 agonist
|
Cenerimod (ACT-334441) is a potent and orally available S1P1 receptor agonist with EC50 of 2.7 nM. |
| PC-45066 |
Amiselimod hydrochloride
S1P1 modulator
|
Amiselimod (MT-1303) hydrochloride is a prodrug S1P1 receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators. |
| PC-42284 |
ONO-7300243
LPA1 inhibitor
|
ONO7300243 is a novel potent, selective, orally available lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 uM. |
| PC-42379 |
CYM-5541
S1P3 agonist
|
CYM-5541 (ML249) is a potent, selective, allosteric and full agonist of S1P3 receptor with EC50 of 72-132 nM. |
| PC-23691 |
TRV045
S1P1 agonist
|
TRV045 is a potent, selective agonist of sphingosine 1-phosphate receptor 1 (S1PR1, S1P1 receptor) without effects on lymphocyte trafficking, shows potential anti-epileptic effects. |
| PC-23606 |
AS2717638
LPA5 antagonist
|
AS2717638 a potent, selective lysophosphatidic acid receptor 5 (LPA5, LPAR5) antagonist, inhibits LPA-induced cAMP accumulation in CHO cells expressing human LPA5 with IC50 of 38 nM. |
| PC-23559 |
GS-2278
LPAR1 antagonist
|
GS-2278 is a potent, selective lysophosphatidic acid receptor 1 (LPAR1, LPA1) antagonist with EC50 of 12 nM in MRTF-A nuclear translocation assay in TWNT4 cells. |
| PC-23526 |
AUY954 hydrochloride
S1P1 agonist
|
AUY954 hydrochloride is a potent, selective sphingosine-1-phosphate (S1P1) receptor agonist with EC50 of 1.2 nM (hS1P1) and 0.9 nM (mS1P1) in γ-GTPS-binding assays, >280-fold selective over S1P2-5. |
| PC-23525 |
AUY954
S1P1 agonist
|
AUY954 is a potent, selective sphingosine-1-phosphate (S1P1) receptor agonist with EC50 of 1.2 nM (hS1P1) and 0.9 nM (mS1P1) in γ-GTPS-binding assays, >280-fold selective over S1P2-5. |
| PC-23381 |
LPA1 agonist CpX
LPA1 agonist
|
LPA1 agonist CpX is a potent, selective agonist of lysophosphatidic acid receptor LPA1 with pEC50 of 5.6 in cell-based calcium mobilization assay, has 30-fold higher agonistic activity as compared with LPA. |
