| Cat. No. |
Product Name |
Information |
| PC-21440 |
NXC736
S1P4 antagonist
|
NXC736 (Vonifimod, SLB736) is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1P4 receptor, S1P4R), has immunomodulatory and anti-fibrotic effects. |
| PC-21209 |
TY-52156
S1P3 inhibitor
|
TY-52156 (TY52156) is a potent, selective S1P3 receptor antagonist with Ki of 110 nM. |
| PC-21122 |
TP0541640
LPA1 antagonist
|
TP0541640 (TP 0541640) is a novel potent LPA1 antagonist with IC50 of 1.6 nM, shows potential for the treatment of lung and skin fibrosis. |
| PC-20833 |
A-971432
S1P5 agonist
|
A-971432 is a potent, highly selective, CNS-penetrant and orally bioavailable agonist of S1P5 receptor with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively. |
| PC-20759 |
ONO-0740556
LPA1 agonist
|
ONO-0740556 is a small molecule agonist of lysophosphatidic acid receptor 1 (LPA1) with EC50 of 0.26 nM (human LPA1), ONO-0740556 is an LPA analog with more potent activity against LPA1. |
| PC-20462 |
LPA2 antagonist 58
LPA2 inhibitor
|
LPA2 antagonist 58 is a highly potent and selective LPA2 receptor antagonist with pIC50 of 8.22 (hLPA2) and 8.19 (mLPA2), >1000-fold selectivity over LPA1 receptor. |
| PC-20419 |
SLB1122168 hydrochloride
Spns2 inhibitor
|
SLB1122168 hydrochloride is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM. |
| PC-20418 |
SLB1122168
Spns2 inhibitor
|
SLB1122168 is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM. |
| PC-20351 |
IMMH002
S1P1 agonist
|
IMMH002 is a potent, selective and orally active S1P1 agonist, IMMH002 can be transformed to IMMH002-P in vivo, IMMH002-P activates S1P1, S1P4, and S1P5 with 12.4, 19.8 and 29.4 nM respectively. |
| PC-49650 |
AM095
LPA1 antagonist
|
AM095 (AM-095) is a potent, selective and orally active lysophosphatidic acid type 1 receptor (LPA1) antagonist with IC50 of 0.98 and 0.73 uM for hLPA1 and mLPA1 in GTP S binding assays, respectively, with no LPA1 agonism. |
| PC-49229 |
H2L5186303
LPA2 antagonist
|
H2L5186303 is a potent, selective LPA2 receptor antagonist with IC50 of 8.9 nM, no significant activity against LPA1 and LPA3 receptors (IC50>1,000 nM), inhibits LPA(2) mediated Erk activation and proliferation of HCT-116 cells. |
| PC-49228 |
UCM-14216
LPA2 antagonist
|
UCM-14216 (UCM14216) is a potent and selective antagonist of type 2 lysophosphatidic acid receptor (LPA2) with KD value of 1.3 nM and IC50 of 1.9 uM. |
