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Cat. No. Product Name Information
PC-73187

S1P5-IN-15

S1P5 antagonist

S1P5-IN-15 is a potent, selective, orally active and brain-penetrant S1P5 antagonist with IC50 of 0.1 nM, no effect on S1P1-4.
PC-72841

ALESIA

S1PR3 agonist

ALESIA is a sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal.
PC-72368

SAR247799

S1P1 agonist

SAR247799 is a potent, selective G protein-biased S1P1 agonist with EC50 of 39 and 19 nM in β-arrestin and internalization assays, respectivey.
PC-72349

BMS-986278

LPA1 antagonist

BMS-986278 (BMS986278) is a potent, selective lysophosphatidic acid receptor 1 (LPA1) antagonist with human LPA1 Kb of 6.9 nM.
PC-35275

SAR-100842

LPA1 antagonist

Fipaxalparant (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.
PC-35273

TAK-615

LPA1 antagonist

TAK-615 (TAK615) is a potent, selective, negative allosteric modulator (NAM) of the LPA1 receptor, partially inhibits the LPA response with IC50 of 91 nM (60% at 10 uM) in calcium mobilisation assays..
PC-35245

BMS-986166

S1P modulator

BMS-986166 (Udifitimod) is a potent, selective S1P receptor modulator for the treatment of ulcerative colitis.
PC-35197

ASP6432

LPA1 antagonist

ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.
PC-43463

Ki16425

LPA1/LPA3 antagonist

Ki16425 (Debio 0719) is a potent, subtype-selective, competitive antagonist of lysophosphatidic acid receptor LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, shows no activity at LPA4, LPA5, LPA6.
PC-43245

S1P1 Agonist 8

S1P1 agonist

S1P1 Agonist 8 is a potent, selective, orally bioavailable S1P1 receptor agonist with EC50 of 35 nM (S1P1 internalization), >100-fold selectivity over against receptor subtypes S1P2-5.
PC-43209

Etrasimod

S1P1 antagonist

Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM.
PC-43000

Siponimod

S1P1/S1P5 modulator

Siponimod (BAF312) is a potent, selective S1P1/S1P5 receptor modulator with EC50 of 0.39/0.0.98 nM, >1,000-fold selectivity over S1P2/3/4.

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