| Cat. No. |
Product Name |
Information |
| PC-60746 |
AB1
S1P2 inhibitor
|
AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs. |
| PC-60745 |
JTE 013
S1P2 inhibitor
|
JTE-013 (JTE013) is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 17 nM and 22 nM for human and rat S1P2, respectively. |
| PC-60340 |
AD 2900
S1P inhibitor
|
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively. |
| PC-60145 |
ONO-0300302
LPA1 antagonist
|
ONO-0300302 (ONO0300302) is a novel potent, slow tight binding LPA1 receptor antagonist with IC50 of 86 nM, Kd of 0.34 nM. |
| PC-70075 |
VPC-23019
S1P1/3 antagonist
|
VPC-23019 is a competitive S1P receptor antagonist with pKi of 7.86 and 5.93 for S1P1 and S1P3, respectively, in radioligand binding assays. |
| PC-60095 |
SPM-242 racemate
S1P3 antagonist
|
SPM-242 racemate is a potent, selective S1P3 antagonist with Ki of 0.25 nM, displays selectivity over other S1P receptors. |
| PC-60094 |
SPM-242
S1P3 antagonist
|
SPM-242 is potent, selective S1P3 antagonist with Ki of 0.25 nM, displays selectivity over other S1P receptors. |
| PC-60049 |
Mocravimod
S1P1 agonist
|
Mocravimod (KRP203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist. |
| PC-42800 |
Fingolimod
S1P receptor agonist
|
Fingolimod (FTY720) is an immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM. |
| PC-42213 |
BMS-986020
LPA1 inhibitor
|
BMS-986020 (BMS986020, AM-152) is a potent, selective, orally available LPA1 receptor antagonist for treating idiopathic pulmonary fibrosis. |
| PC-42656 |
Ponesimod
S1P1 agonist
|
Ponesimod (ACT-128800) is a potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM. |
| PC-45411 |
LPA2 antagonist 1
LPA2 antagonist
|
LPA2 antagonist 1 is a potent, selective LPA2 (EDG4) antagonist with IC50 of 17 nM. |
