| Cat. No. |
Product Name |
Information |
| PC-22266 |
NTRC-824
NTSR2 antagonist
|
NTRC-824 is the first nonpeptide, selective antagonist of neurotensin receptor type 2 (NTS2/NTSR2) with IC50 of 32 nM in FLIPR assays, binding Ki of 202 nM. |
| PC-22265 |
NTRC-739
NTSR2 agonist
|
NTRC-739 is a selective nonpeptide neurotensin receptor type 2 (NTS2/NTSR2) partial agonist with EC50 of 12 nM, binding Ki of 153 nM, displays no activity against NST1. |
| PC-20497 |
SR142948 hydrochloride
neurotensin receptor antagonist
|
SR142948 hydrochloride is a potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM. |
| PC-20496 |
JMV449
NTS1 agonist
|
JMV449 (JMV-449) is a potent, metabolically stable neurotensin receptor agonist peptide with IC50 of 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain. |
| PC-20493 |
ML314
NTR1 agonist
|
ML314 is a selective, brain penetrant full agonist of neurotensin 1 receptor (NTR1) with EC50 of 2.0 uM, shows good selectivity against NTR2 and GPR35. |
| PC-20492 |
ML301
NTR1 agonist
|
ML301 is a selective full (79-93%) neurotensin-1 (NTR1) receptor agonist with EC50 of 2.0-4.1 uM, good selectivity relative to NTR2 and GPR35. |
| PC-38142 |
SBI-553
NTR1 modulator
|
SBI-553 (SBI553) is a potent, selective, β-arrestin-biased, brain penetrant neurotensin receptor 1 (NTR1, NTSR1) allosteric modulator with EC50 of 0.34 uM. |
| PC-61109 |
NTRC-844
NTSR2 antagonist
|
NTRC-844 (NTRC844) is a potent, selective neurotensin receptor type 2 (NTS2, NTSR2) antagonist with Ki of 23 nM, 100-fold selectivity over NTS1 receptor. |
| PC-60948 |
SR142948
Neurotensin receptor antagonist
|
SR142948 is a potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM. |
| PC-60947 |
SR 48692
Neurotensin receptor antagonist
|
SR 48692 (Meclinertant) is a potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity. |
