| Cat. No. |
Product Name |
Information |
| PC-45630 |
Didox
Ribonucleotide reductase inhibitor
|
Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α. |
| PC-42711 |
Raltitrexed
Antifolate
|
Raltitrexed (ZD1694, D1694, ICI-D1694) is a quinazoline antifolate thymidylate synthase (TS) inhibitor with Ki of 62 nM. |
| PC-42266 |
Triapine
RRM2 inhibitor
|
Triapine (3-AP, PAN-811, OCX191, NSC 663249) is a potent inhibitor of ribonucleotide reductase subunit M2 (RRM2) with broad spectrum antitumor activity. |
| PC-42285 |
Acelarin
|
Acelarin (NUC-1031, CPF-31) is a gemcitabine phosphoramidate prodrug that can overcome the key cancer resistance |
| PC-45223 |
Tegafur
|
A chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers. |
| PC-42672 |
5-Azacytidine
|
5-Azacytidine (5-AzaC, Azacitidine) is a chemical analog of Cytidine that inhibits DNA methyltransferase, induces mitochondrial apoptosis and autophagy. |
| PC-26914 |
Piritrexim
DHFR inhibitor, Antifolate
|
Piritrexim (BW301U) is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 of 0.038 and 0.011 uM, respectively, shows antiparasitic, antipsoriatic and antitumor properties. |
| PC-26912 |
Leucovorin
Antifolate
|
Leucovorin (folinic acid, calcium folinate) is a prescription form of reduced folic acid that does not require enzymatic activation by dihydrofolate reductase (DHFR), prevents side effects from certain medications, such as methotrexate. |
| PC-26703 |
PSB-24379
CD39 inhibitor
|
PSB-24379 is a potent, selective inhibitor of ATP-hydrolyzing ectoenzyme nucleoside triphosphate diphosphohydrolase-1 (NTPDase1, CD39) with Ki of 77.4 nM, shows ancillary CD73 inhibition with Ki of 240 nM. |
| PC-26077 |
MSD-914
ACHY inhibitor
|
MSD-914 is a potent, selective S-adenosylhomocysteine hydrolase (AHCY) inhibitor with IC50 of 40 nM, shows broad-spectrum in vitro anti-filovirus activity against EBOV, Marburg virus, and Sudan ebolavirus. |
| PC-24830 |
N3PT
Transketolase inhibitor
|
N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor, N3PT is pyrophosphorylated and then binds to transketolase with Kd of 22 nM. |
| PC-24757 |
POM-1
CD39 inhibitor
|
POM-1 (Sodium metatungstate, Sodium polyoxotungstate) is an effective NTPDase inhibitor with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively, inhibits ATP breakdown and shows anti-inflammatory and anti-cancer effect. |
