| Cat. No. |
Product Name |
Information |
| PC-63498 |
TAS-114
dUTPase/DPD inhibitor
|
TAS-114 is a first-in-class, potent, dual dUTPase/DPD (dihydropyrimidine dehydrogenase) inhibitor with Ki of 0.13/2.14 uM, respectively. |
| PC-62751 |
5-NITP
Ribonucleotide reductase inhibitor
|
5-NITP is a non-natural nucleotide that inhibits ribonucleotide reductase (hRR) with IC50 of 170 uM, demonstrates anti-cancer effects against leukemia cells by altering cell-cycle progression. |
| PC-62750 |
5-NIdR
Nucleoside analog
|
5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression. |
| PC-61684 |
6-Ethylthioinosine
|
6-Ethylthioinosine (6-ETI, NSC 39368, SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines. |
| PC-61365 |
Cedazuridine
|
Cedazuridine (E7727) is a novel cytidine deaminase inhibitor, and a componet of ASTX727 for treatment of hematologic malignancies.. |
| PC-61331 |
Sapacitabine
|
Sapacitabine (CYC-682) is an orally available, nucleoside analog prodrug of CNDAC that interferes with DNA synthesis by causing single-strand DNA breaks. |
| PC-70217 |
NSAH
Ribonucleotide reductase inhibitor
|
Ribonucleotide reductase inhibitor NASH is a nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM. |
| PC-46012 |
5-Fluorouracil
|
An uridine analog that is a widely used chemotherapeutic agent. |
| PC-45149 |
Gemcitabine
|
Gemcitabine (NSC 613327, LY188011) is a synthetic pyrimidine nucleoside prodrug that works by ihibiting the enzyme ribonucleotide reductase (RNR) and blocking the creation of new DNA. |
| PC-42402 |
MT-DADMe-ImmA
|
A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM. |
| PC-45630 |
Didox
Ribonucleotide reductase inhibitor
|
Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α. |
| PC-42711 |
Raltitrexed
|
A quinazoline antifolate thymidylate synthase (TS) inhibitor with Ki of 62 nM. |
