| Cat. No. |
Product Name |
Information |
| PC-22531 |
OR0642
dCK inhibitor
|
OR0642 is a highly potent, specific deoxycytidine kinase (dCK) inhibitor with IC50 of 2.2 nM. |
| PC-22447 |
L-Isoleucine
Nucleoside analog
|
L-isoleucine is the L-enantiomer of isoleucine, has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. |
| PC-22379 |
5-Fluorocytosine
Nucleoside analog
|
5-Fluorocytosine (Flucytosine) is an organofluorine compound and antifungal agent, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida, neoplasm infection, as well as anticaner acitvities. |
| PC-21771 |
TH7528
SAMHD1 inhibitor
|
TH7528 (TH-7528) is a specific small-molecule inhibitor against the dNTP triphosphohydrolase (dNTPase) SAMHD1, inhibits the enzymatic activities of SAMHD1 against dGTP, Cl-F-ara-ATP, and ara-CTP with IC50 of 4.5, 2.8 and 2.6 uM, respectively. |
| PC-20287 |
JLT048
TDP1/2 inhibitor
|
JLT048 is a small molecule inhibitor of tyrosyl-DNA-phosphodiesterases 1 and 2 (TDP1 and TDP2) with IC50 of 7.7 and 32 uM, respectively. |
| PC-20268 |
Teriflunomide
DHODH inhibitor
|
Teriflunomide (RS-61980, A-771726) is the active metabolite of leflunomide, acts as an immunomodulatory agent by inhibiting pyrimidine synthesis, inhibits dihydroortate dehydrogenase (DHODH, EC 1.3.3.1) with IC50 of 2.7 uM. |
| PC-20259 |
Pyrazofurin
|
Pyrazofurin (Pyrazomycin, NSC 143095) is a nucleoside analog that potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. |
| PC-20182 |
dCK inhibitor DI-39
dCK inhibitor
|
DI-39 is a compound that inhibits the salvage pathways by blocking the enzyme, deoxycytidine kinase (dCK), induces replication stress in ALL cancer cell models through dCTP depletion. |
| PC-49673 |
PSB-071
NTPDase inhibitor
|
PSB-071 (PSB071) is a small molecule inhibitor of nucleoside triphosphate diphosphohydrolases (NTPDase). |
| PC-49655 |
PSB-0952
CD73 inhibitor
|
PSB-0952 (PSB0952) is a potent, selective ecto-5'-Nucleotidase (eN, CD73) inhibitor with Ki of 260 nM, >150-fold selectivity over NTPDases and P2Y receptor subtypes P2Y2, P2Y4, P2Y6, and P2Y12. |
| PC-49654 |
PSB-0963
CD73 inhibitor
|
PSB-0963 (PSB0963) is a potent, selective ecto-5'-Nucleotidase (eN, CD73) inhibitor with Ki of 150 nM, >100-fold selectivity over NTPDases. |
| PC-49421 |
Oroxylin A
Transketolase inhibitor
|
Oroxylin A is a small molecule transketolase (TKT) inhibitor with SPR KD of 70.7 uM, inhibits hepatocellular carcinoma growth in vitro and in vivo. |
