| Cat. No. |
Product Name |
Information |
| PC-20257 |
Acivicin hydrochloride
GATases inhibitor
|
Acivicin hydrochloride (AT-125, U-42,126, NSC 163501) is an analog of glutamine and inhibits glutamine amidotransferases (GATases) in the purine and pyrimidine biosynthetic pathways. |
| PC-20256 |
Acivicin
GATases inhibitor
|
Acivicin is an analog of glutamine and inhibits glutamine amidotransferases (GATases) in the purine and pyrimidine biosynthetic pathways. |
| PC-20254 |
N-phosphonacetyl-L-aspartate
ATCase inhibitor
|
N-phosphonacetyl-L-aspartate (PALA, NSC 224131, Sparfosic acid) is a potent and reversible inhibitor of de novo pyrimidine biosynthesis, specifically inhibits aspartate transcarbamylase (ATCase). |
| PC-49549 |
NUC-7738
|
NUC-7738 is a ProTide and 5'-aryloxy phosphoramidate prodrug of 3'-Deoxyadenosine (3'-dA, Cordycepin), NUC-7738 is an effective anticancer drug in a panel of solid and hematological cancer cell lines. |
| PC-49170 |
F-aza-T-dCyd
Cytidine analog
|
F-aza-T-dCyd (NSC801845) is a novel cytidine analog and is more efficacious than aza-T-dCyd in cell culture and mouse xenograft studies in HCT-116 human colon carcinoma. |
| PC-35966 |
Tipiracil hydrochloride
TPase inhibitor
|
Tipiracil hydrochloride (TPase inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibit uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase. |
| PC-35965 |
Thymidine Phosphorylase inhibitor 8g
|
Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g) is a novel potent, selective inhibitor of human thymidine phosphorylase (hTP) with IC50 of 0.12 uM. |
| PC-61684 |
6-Ethylthioinosine
|
6-Ethylthioinosine (6-ETI, NSC 39368, SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines. |
| PC-61365 |
Cedazuridine
|
Cedazuridine (E7727) is a novel cytidine deaminase inhibitor, and a componet of ASTX727 for treatment of hematologic malignancies.. |
| PC-46012 |
5-Fluorouracil
|
An uridine analog that is a widely used chemotherapeutic agent. |
| PC-45149 |
Gemcitabine
|
Gemcitabine (NSC 613327, LY188011) is a synthetic pyrimidine nucleoside prodrug that works by ihibiting the enzyme ribonucleotide reductase (RNR) and blocking the creation of new DNA. |
| PC-42402 |
MT-DADMe-ImmA
|
A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM. |
