| Cat. No. |
Product Name |
Information |
| PC-21770 |
TH6342
SAMHD1 inhibitor
|
TH6342 (TH-6342) is a specific small-molecule inhibitor against the dNTP triphosphohydrolase (dNTPase) SAMHD1, inhibits the enzymatic activities of SAMHD1 against dGTP, Cl-F-ara-ATP, and ara-CTP with IC50 of 9.6, 11.0 and 5.8 uM, respectively. |
| PC-20288 |
TCP2 inhibitor 163
TDP2 inhibitor
|
TCP2 inhibitor 163 is a potent, selective inhibitor of tyrosyl-DNA-phosphodiesterases 1 with EC50 of 40 nM in NPPP assays, shows selectivity against TDP1 and APE-1. |
| PC-20257 |
Acivicin hydrochloride
GATases inhibitor
|
Acivicin hydrochloride (AT-125, U-42,126, NSC 163501) is an analog of glutamine and inhibits glutamine amidotransferases (GATases) in the purine and pyrimidine biosynthetic pathways. |
| PC-20256 |
Acivicin
GATases inhibitor
|
Acivicin is an analog of glutamine and inhibits glutamine amidotransferases (GATases) in the purine and pyrimidine biosynthetic pathways. |
| PC-20254 |
N-phosphonacetyl-L-aspartate
ATCase inhibitor
|
N-phosphonacetyl-L-aspartate (PALA, NSC 224131, Sparfosic acid) is a potent and reversible inhibitor of de novo pyrimidine biosynthesis, specifically inhibits aspartate transcarbamylase (ATCase). |
| PC-49549 |
NUC-7738
|
NUC-7738 is a ProTide and 5'-aryloxy phosphoramidate prodrug of 3'-Deoxyadenosine (3'-dA, Cordycepin), NUC-7738 is an effective anticancer drug in a panel of solid and hematological cancer cell lines. |
| PC-49170 |
F-aza-T-dCyd
Cytidine analog
|
F-aza-T-dCyd (NSC801845) is a novel cytidine analog and is more efficacious than aza-T-dCyd in cell culture and mouse xenograft studies in HCT-116 human colon carcinoma. |
| PC-38899 |
TAS1553
Ribonucleotide reductase inhibitor
|
TAS1553 is a highly potent, selective small-molecule inhibitor of ribonucleotide reductase (RNR) with enzyme IC50 of 54.2 nM, binds to R1 subunit with Kd of 34.9 nM, disrupts PPI between R1 and R2 subunit. |
| PC-35966 |
Tipiracil hydrochloride
TPase inhibitor
|
Tipiracil hydrochloride (TPase inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibit uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase. |
| PC-35965 |
Thymidine Phosphorylase inhibitor 8g
|
Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g) is a novel potent, selective inhibitor of human thymidine phosphorylase (hTP) with IC50 of 0.12 uM. |
| PC-62751 |
5-NITP
Ribonucleotide reductase inhibitor
|
5-NITP is a non-natural nucleotide that inhibits ribonucleotide reductase (hRR) with IC50 of 170 uM, demonstrates anti-cancer effects against leukemia cells by altering cell-cycle progression. |
| PC-62750 |
5-NIdR
Nucleoside analog
|
5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression. |
