| Cat. No. |
Product Name |
Information |
| PC-38840 |
FKK6
hPXR agonist
|
FKK6 (Felix Kopp Kortagere 6) is a specific human pregnane X receptor (hPXR) agonist with IC50 of 1.56 uM in a cell‐free competitive hPXR TR‐FRET‐binding assays. |
| PC-62524 |
SJB7
PXR agonist
|
SJB7 is a close analog of SPA70 and hPXR agonist, interacts with the ligand-binding domain (LBD) of hPXR. |
| PC-62523 |
SPA70
PXR antagonist
|
SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells. |
| PC-60008 |
C2BA-4
PXR agonist
|
C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM. |
| PC-42261 |
SR12813
PXR agonist
|
SR12813 (GW485801) is potent and efficacious pregnane X receptor (PXR) activator with EC50 of 200 and 700 nM for human and rabbit PXR, respectively. |
| PC-22402 |
SJPYT-328
PXR agonist
|
SJPYT-328 is a potent, selective pregnane X receptor (PXR) agonist with binding IC50 of 48 nM, agonism IC50 of 7.1 nM. |
| PC-22401 |
SJPYT-331
PXR antagonist
|
SJPYT-331 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 3.6 nM, antagonistic IC50 of 7.1 nM. |
| PC-22400 |
SJPYT-306
PXR antagonist
|
SJPYT-306 is a potent, selective dual antagonist and inverse agonist of pregnane X receptor (PXR) with binding IC50 of 6 nM, inverse agonist and antagonist IC50 of 1 nM and 14 nM, respectively. |
| PC-22399 |
SJPYT-310
PXR antagonist
|
SJPYT-310 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 4 nM, antagonistic IC50 of 9 nM. |
| PC-21198 |
SJPYT-318
PXR agonist
|
SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1. |
