| Cat. No. |
Product Name |
Information |
| PC-24972 |
Ocadusertib
RIPK1 inhibitor
|
Ocadusertib (LY3871801, R552) is a potent and selective, allosteric inhibitor of RIPK1 with IC50 of 12-38 nM. |
| PC-24570 |
LK01003
RIPK3 inhibitor
|
LK01003 is a potent, highly selective inhibitor targeting RIPK3 with IC50 of 2 nM in ADP-Glo assays, shows anti-necroptotic activities in L929 cells with EC50 of 3.7 uM. |
| PC-22143 |
UH15-38
RIPK3 inhibitor
|
UH15-38 is a potent, specific receptor interacting protein kinase 3 (RIPK3) inhibitor with IC50 of 20 nM in NanoBRET assays, potently and selectively blocks IAV-triggered necroptosis in alveolar epithelial cells in vivo. |
| PC-21478 |
GSK840
RIPK3 inhibitor
|
GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis. |
| PC-21082 |
Zharp2-1
RIPK2 inhibitor
|
Zharp2-1 is a novel potent, selective RIPK2 inhibitor with IC50 of 38.5 nM in ADP-Glo kinase assay, effectively blocks RIPK2 kinase function and NOD-mediated NF-κB/MAPK activation. |
| PC-20063 |
Oditrasertib
RIPK1 inhibitor
|
Oditrasertib (DNL788, SAR443820) is a potent, selective, orally bioavailable, brain penetrant inhibitor RIPK1 inhibitor with IC50 of 3.16 nM in human PBMCs and 1.6 nM in induced pluripotent stem cell (iPSC)-derived microglia. |
| PC-20036 |
Flizasertib
RIPK1 inhibitor
|
Flizasertib (GDC-8264) is a potent, selective receptor-interacting protein 1 (RIP1, RIPK1) inhibitor with Kiapp of 0.71 nM. |
| PC-49810 |
RIPK2 inhibitor 3
RIPK2 inhibitor
|
RIPK2 inhibitor 3 is a potent, selective inhibitor of RIP2 kinase (RIPK2), displays equivalent potency to inhibitor RIPK2 inhibitor 3 in biochemical assays, phosphate ester prodrug. |
| PC-49455 |
RI-962
RIPK1 inhibitor
|
RI-962 (RI 962) is a potent and selective RIPK1 inhibitor with IC50 of 5.9 nM in ADP-Glo assays. |
| PC-49449 |
Zharp1-211
RIPK1 inhibitor
|
Zharp1-211 is a potent, selective, type II inhibitor of RIPK1 kinase with IC50 of 53 nM and binding Kd of 8.7 nM. |
| PC-49126 |
GNE684
RIPK1 inhibitor
|
GNE684 (GNE 684) is a potent, cross-species, specific RIP1 kinase (RIPK1) inhibitor with IC50 of 21, 189 and 691 nM for human, mouse and rat RIP1, respectively. |
| PC-47116 |
AS3334034
RIPK2 inhibitor
|
AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively. |
