| Cat. No. |
Product Name |
Information |
| PC-38781 |
Dusquetide
p62 modulator
|
Dusquetide (SGX-942, SGX94) is a 5-amino acid peptide, cell membrane penetrant innate defense regulator (IDR) that modulates the innate immune response to both PAMPs and DAMPs, targets the ZZ domain of p62 and modulates the p62-RIP1 complex. |
| PC-38621 |
ZJU-37
RIPK1 inhibitor
|
ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM. |
| PC-38490 |
GSK-843
RIPK3 inhibitor
|
GSK-843 (GSK'843) is a specific small molecule receptor-interacting protein kinase 3 (RIPK3) inhibitor, binds to RIP3 kinase domain with high affinity (IC50=8.6 nM). |
| PC-73179 |
GSK2983559-AM
RIPK2 inhibitor
|
GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM. |
| PC-73178 |
GSK2983559
RIPK2 inhibitor
|
GSK2983559 is a potent, selective and orally active receptor interacting protein 2 kinase (RIPK2) inhibitor with IC50 of 7 nM. |
| PC-73017 |
PK68
RIPK1 inhibitor
|
PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively). |
| PC-73007 |
Necrostatin-34
RIPK1 inhibitor
|
Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM. |
| PC-72999 |
GSK3145095
RIPK1 inhibitor
|
GSK3145095 (GSK 3145095) is a potent, selective RIP1 Kinase (RIPK1) inhibitor with IC50 of 6.3 nM. |
| PC-72533 |
Eclitasertib
RIPK1 inhibitor
|
Eclitasertib (DNL-758, SAR-443122) is a potent, orally bioavailable, small-molecule RIPK1 inhibitor with IC50 of <1 uM, shows anti-necroptosis activity on U937 human cell line with pIC50 of 7.91. |
| PC-72529 |
GW440139B
RIPK3 inhibitor
|
GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM. |
| PC-72528 |
Nigratine
RIPK1 inhibitor
|
Nigratine (6E11) is a highly specific, non-ATP competitive inhibitor of RIPK1 kinase (IC50=1.6 uM), inhibits necroptosis and ferroptosis. |
| PC-72473 |
ZB-R-55
RIPK1 inhibitor
|
ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772. |
