| Cat. No. |
Product Name |
Information |
| PC-25449 |
Zharp1-163
Ferroptosis/necroptosis inhibitor
|
Zharp1-163 is a dual inhibitor of ferroptosis and necroptosis, effectively blocks ferroptosis by reducing reactive oxygen species (ROS) levels and inhibits necroptosis by potently and selectively targeting RIPK1 kinase (IC50=406.1 nM). |
| PC-25227 |
Compound RP20
RIPK2 inhibitor
|
Compound RP20 is a potent, selective RIPK2 inhibitor with IC50 of 13 nM, does not inhibit RIPK1. |
| PC-24571 |
LK01045
RIPK3 inhibitor
|
LK01045 is a potent, highly selective inhibitor targeting RIPK3 with IC50 of 16 nM in ADP-Glo assays. |
| PC-24512 |
SZM-1209
RIPK1 inhibitor
|
SZM-1209 is a potent, specific RIPK1 inhibitor with Kd value of 85 nM, >100-fold selective over RIPK3, exhibits anti-necroptosis activity against human HT-29 cells with EC50 of 22.4 nM. |
| PC-24511 |
SIR1-365
RIPK1 inhibitor
|
SIR1-365 is a highly potent, selective, and metabolically stable allosteric kinase inhibitor of RIPK1. |
| PC-24510 |
RIPK1 inhibitor 13c
RIPK1 inhibitor
|
RIPK1 inhibitor 13c is a potent, selective RIPK1 inhibitor with IC50 of 59.8 nM and Kd of 3.5 nM, effectively prevented the necroptosis (HT-29, EC50=4.58 nM) by inhibiting phosphorylation of RIPK1/RIPK3/MLKL single pathway. |
| PC-24135 |
Fosizensertib
RIPK1 inhibitor
|
Fosizensertib is a potent, selective RIPK1 inhibitor. |
| PC-23024 |
Citronellol
RIPK1 agonist
|
Citronellol is an orally active inducer of apoptosis and RIPK1 agonist. |
| PC-22669 |
Nec-1s
Necroptosis inhibitor, RIPK1 inhibitor
|
Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO. |
| PC-22668 |
Necrostatin-5
Necroptosis inhibitor, RIPK1 inhibitor
|
Necrostatin-5 (Nec-5) is a potent, specific necroptosis inhibitor with EC50 of 240 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1). |
| PC-22667 |
Necrostatin-1
Necroptosis inhibitor, RIPK1 inhibitor
|
Necrostatin-1 (Nec-1) is a potent, specific and BBB-permeable necroptosis inhibitor with EC50 of 490 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1) with EC50 of 182 nM. |
| PC-21707 |
RIPK1 inhibitor 62
RIPK1 inhibitor
|
RIPK1 inhibitor 62 is a potent, selective, orally bioavailable type-II kinase inhibitor of RIPK1 with IC50 of 3.5 nM (hRIPK1), 200-fold less potent against hRIPK3. |
