| Cat. No. |
Product Name |
Information |
| PC-62515 |
Rheb inhibitor NR1
Rheb inhibitor
|
Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK. |
| PC-62450 |
CPYPP
DOCK2-Rac1 inhibitor
|
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction. |
| PC-62448 |
Phox-I1
p67phox-Rac1 inhibitor
|
Phox-I1 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=100 nM) and interferes with Rac1-GTP interaction with p67phox. |
| PC-62365 |
ML282
Rab7 inhibitor
|
ML282 (CID 1067700) is a competitive small molecule inhibitor of nucleotide binding by Ras-related GTPases, binds the nucleotide binding pocket of Rab7 with Ki value of 13 nM. |
| PC-61470 |
Rac1-IN-6
Rac1 inhibitor
|
Rac1-IN-6 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM. |
| PC-61469 |
Rac1-IN-1
Rac1 inhibitor
|
Rac1-IN-1 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM. |
| PC-61468 |
MLS000532223
Rho GTPases inhibitor
|
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 of 16-120 uM. |
| PC-61174 |
SecinH3
small GEFs inhibitor
|
SecinH3 is a selective inhibitor of small GEFs of the cytohesin family, blocks human, mouse and Drosophila cytohesins with IC50 of 2.4 to 5.6 uM. |
| PC-60905 |
MBQ-167
Rac/Cdc42 inhibitor
|
MBQ-167 (MBQ 167, MBQ167) is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells. |
| PC-60847 |
Nexinhib 20
Rab27a inhibitor
|
Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors. |
| PC-60611 |
NAV 2729
ARF6 inhibitor
|
NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays. |
| PC-44661 |
NSC 23766 trihydrochloride
Rac inhibitor
|
NSC 23766 trihydrochloride is a specific small molecule inhibitor of Rac GTPase. |
