| Cat. No. |
Product Name |
Information |
| PC-42292 |
CEP-40783
AXL/c-Met inhibitor
|
CEP-40783 (CEP40783, RXDX-106) is a potent and selective AXL/c-Met inhibitor with IC50 of 7 nM/12 nM. |
| PC-24514 |
UNC8212
TAM kinases inhibitor
|
UNC8212 is a potent, selective inhibitor of TAM-family (TYRO3, AXL, and MERTK) tyrosine kinases with IC50 of 1.5 nM, 1.3 nM, and 6.7 nM for MERTK, AXL and TYRO3 respectively. |
| PC-24400 |
UNC9435
TYRO3/MERTK inhibitor
|
UNC9435 is a potent, dual TYRO3/MERTK inhibitor with IC50 of 3.7/1.1 nM respectively, has 46-fold and 120-fold selectivity of MERTK over AXL and FLT3, respectively. |
| PC-24218 |
UNC9426
TYRO3 inhibitor
|
UNC9426 is a potent, specific TYRO3 inhibitor with IC50 of 2.1 nM, has 276- and 90-fold selectivity over MERTK and AXL respectively. |
| PC-23043 |
UNC2541
Mer inhibitor
|
UNC2541 is a potent, specific Mer tyrosine kinase (MerTK) inhibitor with IC50 of 4.4 nM, >25-fold selective over Tyro3, Axl, and FLT3, shows EC50 of 550 nM in pMerTK ELISA assays. |
| PC-23042 |
UNC8969
Mer/Axl inhibitor
|
UNC8969 is a potent, selective, macrocyclic dual MerTK/Axl inhibitor with IC50 of 1.1/5.3 nM respectively, >12-fold selectivity over TYRO3 and FLT3. |
| PC-23041 |
A-910
Mer/Axl inhibitor
|
A-910 is a highly potent and selective, orally active dual MerTK/Axl inhibitor with IC50 of 0.2/0.9 nM respectively, >200-fold selective over Tyro3. |
| PC-50012 |
S49076 hydrochloride
|
S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2. |
