| Cat. No. |
Product Name |
Information |
| PC-20332 |
INCB081776
AXL/MER inhibitor
|
INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3. |
| PC-20023 |
Adrixetinib
Axl/Mer inhibitor
|
Adrixetinib is a small molecule inhibitor of Axl/Mer RTK. |
| PC-49565 |
R992
Mer inhibitor
|
R992 (MERTK inhibitor) is a novel potent, selective and orally bioavailable inhibitor of Mer tyrosine kinase (MerTK) with IC50 of 18 nM in ADP-Glo assays. |
| PC-72446 |
KRCT-6j
TYRO3 inhibitor
|
KRCT-6j is a potent and selective TYRO3 inhibitor, 300-fold selectivity for TYRO3 over both AXL and MerTK. |
| PC-72371 |
UNC2250
Mer inhibitor
|
UNC2250 is a potent, selective Mer inhibitor with IC50 of 1.7 nM, displays >100-fold selectivity over Axland Tyro3. |
| PC-50012 |
S49076 hydrochloride
|
S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2. |
| PC-42994 |
UNC2025 hydrochloride
|
UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer. |
| PC-61780 |
TAM-IN-1
|
TAM-IN-1 is a highly potent, macrocyclic inhibitor of Mer and Axl with Ki of <50 pM and 130 pM, respectively.. |
| PC-61325 |
N-butylidenephthalide
|
A natural compound derived from Angelica sinensis that inhibits malignant brain tumor growth in vitro and in vivo. |
| PC-45668 |
Glesatinib hydrochloride
|
Glesatinib (MGCD-265) is a tyrosine kinase inhibitor that potently and selectively inhibits Met and Axl kinase.. |
