| Cat. No. |
Product Name |
Information |
| PC-24678 |
AB801
Axl inhibitor
|
Ligritinib (AB801) is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays. |
| PC-20336 |
Bemcentinib
Axl inhibitor
|
Bemcentinib (R428, BGB324) is potent, selective and orally bioavailable inhibitor of Axl kinase with IC50 of 14 nM, also is an effective blocker of FAM171A2-α-syn fibril interaction both in vitro and in vivo. |
| PC-20335 |
UNC2881
Mer inhibitor
|
UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3. |
| PC-20334 |
NPS-1034
MET-AXL inhibitor
|
NPS-1034 (NPS1034) is a potent, dual MET and AXL inhibitor with IC50 of 48 and 10.3 nM, respectively. |
| PC-20332 |
INCB081776
AXL/MER inhibitor
|
INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3. |
| PC-20023 |
Adrixetinib
Axl/Mer inhibitor
|
Adrixetinib is a small molecule inhibitor of Axl/Mer RTK. |
| PC-49565 |
R992
Mer inhibitor
|
R992 (MERTK inhibitor) is a novel potent, selective and orally bioavailable inhibitor of Mer tyrosine kinase (MerTK) with IC50 of 18 nM in ADP-Glo assays. |
| PC-49059 |
MRX-2843
Mer inhibitor
|
MRX-2843 (UNC2371) is a potent, selective, orally available ATP-competitive type 1 inhibitor of both Mer and Flt3 with IC50 of 1.3 and 1.0 nM, respectively. |
| PC-73130 |
ONO-7475
Axl inhibitor
|
ONO-7475 (Tamnorzatinib) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations. |
| PC-72649 |
UNC5293
MER inhibitor
|
UNC5293 (UNC-5293) is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 0.9 nM, Ki 0.19 nM. |
| PC-72618 |
PF-07265807
Axl/Mer inhibitor
|
PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. |
| PC-72617 |
AZ14145845
Axl/Mer inhibitor
|
AZ14145845 (Dual Axl-Mer inhibitor 32) is a potent, selective dual Axl/Mer inhibitor with pIC50 of 7.0/7.8. |
