| Cat. No. |
Product Name |
Information |
| PC-28326 |
(±)-10-Hydroxycamptothecin
Topo I inhibitor
|
(±)-10-Hydroxycamptothecin ((±)-10-HCPT) is an indole alkaloid that inhibits the activity of topoisomerase I (Topo I), shows broad spectrum of anticancer activity. |
| PC-28248 |
Doxorubicin
Topoisomerase inhibitor
|
Doxorubicin (Hydroxydaunorubicin) is a cytotoxic anthracycline antibiotic with anti-cancer chemotherapy activity, is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50 of 0.8 μM and 2.67 μM, respectively. |
| PC-28247 |
Berubicin hydrochloride
Topo II inhibitor
|
Berubicin hydrochloride (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison. |
| PC-28246 |
Berubicin
Topo II inhibitor
|
Berubicin (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison. |
| PC-27848 |
Camptothecin
Topo I inhibitor
|
Camptothecin (CPT) is a kind of alkaloid and potent specific DNA topoisomerase I (Topo I) inhibitor with IC50 of 679 nM, exhibits broad antineoplastic activity against multiple cancers. |
| PC-27641 |
Chrysosplenetin
CAS 603-56-5
|
Chrysosplenetin is an o-methylated flavonols isolated from the leaves of Laggera pterodonta with anti-cancer effect, shows strong activity in vitro against EV71 with IC50 of 0.2 uM, also shows neuraminidase inhibitory activity, inhibits topoisomerase I and II. |
| PC-27536 |
Etoposide
Topo II inhibitor, CD44 inhibitor
|
Etoposide (VP-16-213) is a topoisomerase II inhibitor that disrupts DNA replication and transcription, induces cell cycle arrest, apoptosis and autophagy, also inhibits Hyaluronic acid (HA)-CD44 interaction. |
| PC-25511 |
Banoxantrone dihydrochloride
Topo II inhibitor
|
Banoxantrone dihydrochloride (AQ4N) is an alkylaminoanthraquinone-di-N-oxide anticancer prodrug, potentiates the anti-tumour effect of cisplatin, AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4, which is a stable, DNA-affinic compound and potent topoisomerase II inhibitor. |
| PC-25320 |
TAS-103 dihydrochloride
Topoisomerase inhibitor
|
TAS-103 dihydrochloride (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively. |
| PC-25319 |
TAS-103
Topoisomerase inhibitor
|
TAS-103 (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively. |
| PC-24967 |
Annamycin
Topo II inhibitor
|
Annamycin (Naxtarubicin) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo, intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis. |
| PC-24928 |
Merbarone
Topo II inhibitor
|
Merbarone (NSC 336628) is a potent, orally active DNA topoisomerase II (Topo II) inhibitor, inhibits topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. |
