| Cat. No. |
Product Name |
Information |
| PC-61905 |
Epolactaene
Topo II inhibitor
|
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells. |
| PC-61874 |
XR-5000
Topoisomerase inhibitor
|
XR-5000 (Acridine Carboxamide;DACA;NSC 601316;SN-22995) is an inhibitor of topoisomerase I and II for treatment of various types of cancers. |
| PC-61465 |
C-1311 dihydrochloride
Topo II inhibitor
|
C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II. |
| PC-60558 |
GPX-150
Topo II inhibitor
|
GPX-150 (DIDOX, 5-imino-13-deoxy-doxorubicin) is a doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
| PC-45667 |
SW-044248
Topo I inhibitor
|
SW-044248 is a potent, selective inhibitor of Topoisomerase I (Topo I), inhibits Top I differently from camptothecin, shows selective toxicity for some NSCLC cell lines. |
| PC-45203 |
Idarubicin hydrochloride
Topo II inhibitor
|
Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells. |
| PC-42763 |
Amonafide
Topo II inhibitor
|
Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. |
| PC-42639 |
Betulinic acid
Topo II inhibitor
|
Betulinic acid (Betulic acid) is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties. |
| PC-42643 |
Voreloxin
Topo II inhibitor
|
Voreloxin (SNS-595;Vosaroxin;AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively. |
| PC-25511 |
Banoxantrone dihydrochloride
Topo II inhibitor
|
Banoxantrone dihydrochloride (AQ4N) is an alkylaminoanthraquinone-di-N-oxide anticancer prodrug, potentiates the anti-tumour effect of cisplatin, AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4, which is a stable, DNA-affinic compound and potent topoisomerase II inhibitor. |
| PC-25441 |
(S)-10-Hydroxycamptothecin
Topo I inhibitor, DHHC9 inhibitor
|
(S)-10-Hydroxycamptothecin (10-HCPT, 10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor with remarkable apoptosis-inducing effect, also is a potent DHHC9 inhibitor that effectively suppressed adenocarcinoma cell migration. |
| PC-25320 |
TAS-103 dihydrochloride
Topoisomerase inhibitor
|
TAS-103 dihydrochloride (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively. |
