| Cat. No. |
Product Name |
Information |
| PC-60558 |
GPX-150
|
GPX-150 (DIDOX, 5-imino-13-deoxy-doxorubicin) is a doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
| PC-45667 |
SW-044248
Topo I inhibitor
|
SW-044248 is a potent, selective inhibitor of Topoisomerase I (Topo I), inhibits Top I differently from camptothecin, shows selective toxicity for some NSCLC cell lines. |
| PC-45203 |
Idarubicin hydrochloride
Topo II inhibitor
|
Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells. |
| PC-42763 |
Amonafide
Topo II inhibitor
|
Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. |
| PC-42639 |
Betulinic acid
Topo II inhibitor
|
Betulinic acid (Betulic acid) is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties. |
| PC-42643 |
Voreloxin
Topo II inhibitor
|
Voreloxin (SNS-595;Vosaroxin;AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively. |
| PC-49305 |
Doxorubicin hydrochloride
Topo II inhibitor
|
Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin, Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II. |
