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Cat. No. Product Name CAS No. Information
PC-61492

BMS-823778

1140898-87-8 BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2.
PC-60448

BI 135585

1114561-85-1 BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.
PC-60371

UE2343

1346013-80-6 UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.
PC-45408

PF-915275

857290-04-1 A specific and potent inhibitor of the human11β-HSD1 with Ki of 2.3 nM and in vitro HEK293 EC50 of 15 nM, with minimal inhibitory activity toward the mouse enzyme (Ki=750 nM).
PC-45407

BVT-14225

376638-65-2 A selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.
PC-45406

BVT-2733

376640-41-4 A non-steroidal, isoform-selective inhibitor of mouse 11β-HSD1 with Ki of 1 uM.
PC-35792

BMS-823778 free base

1140897-32-0 BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2.

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