| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-61492 |
BMS-823778
|
1140898-87-8 |
BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
| PC-60448 |
BI 135585
|
1114561-85-1 |
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively. |
| PC-60371 |
UE2343
|
1346013-80-6 |
UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2. |
| PC-45408 |
PF-915275
|
857290-04-1 |
A specific and potent inhibitor of the human11β-HSD1 with Ki of 2.3 nM and in vitro HEK293 EC50 of 15 nM, with minimal inhibitory activity toward the mouse enzyme (Ki=750 nM). |
| PC-45407 |
BVT-14225
|
376638-65-2 |
A selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM. |
| PC-45406 |
BVT-2733
|
376640-41-4 |
A non-steroidal, isoform-selective inhibitor of mouse 11β-HSD1 with Ki of 1 uM. |
| PC-35792 |
BMS-823778 free base
|
1140897-32-0 |
BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
