| Cat. No. |
Product Name |
Information |
| PC-62812 |
KGP-420
Cathepsin L inhibitor
|
KGP-420 is the water-soluble phosphate prodrug of KGP-94 in vivo studies, KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM. |
| PC-62811 |
LY-3000328
Cathepsin S inhibitor
|
LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM. |
| PC-61421 |
ONO-5334
Cathepsin K inhibitor
|
ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. |
| PC-61355 |
GB111-NH2
Cathepsin inhibitor
|
GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S. |
| PC-60946 |
GSK 2793660
Cathepsin C inhibitor
|
GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM. |
| PC-60705 |
MIV-247
Cathepsin S inhibitor
|
MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S). |
| PC-60641 |
L-006235
Cathepsin K inhibitor
|
L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S. |
| PC-60528 |
RO5459072
Cathepsin S inhibitor
|
RO5459072 (Petesicatib, RG7625) is a potent, selective cathepsin S (Cat-S) inhibitor, inhibits human Cat-S with apparent IC50 of 0.1 nM and murine Cat-S of 0.3 nM. |
| PC-42094 |
Aloxistatin
Cathepsin B inhibitor
|
Aloxistatin (E64d) is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets. |
| PC-45438 |
Leupeptin hemisulfate
Proteases inhibitor
|
Leupeptin hemisulfate is a potent, reversible inhibitor of cysteine, serine, and threonine proteases, inhibits cathepsin B (Ki=6 nM), calpain (Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 uM), and kallikrein (Ki=19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin. |
| PC-42108 |
CA-074 methyl ester
Cathepsin B inhibitor
|
CA-074 methyl ester is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM. |
| PC-42147 |
Odanacatib
Cathepsin K inhibitor
|
Odanacatib (MK-0822) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 0.2 nM. |
