| Cat. No. |
Product Name |
Information |
| PC-60641 |
L-006235
Cathepsin K inhibitor
|
L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S. |
| PC-60528 |
RO5459072
Cathepsin S inhibitor
|
RO5459072 (Petesicatib, RG7625) is a potent, selective cathepsin S (Cat-S) inhibitor, inhibits human Cat-S with apparent IC50 of 0.1 nM and murine Cat-S of 0.3 nM. |
| PC-60297 |
AZD7986
CatC inhibitor
|
AZD7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 (cathepsin C, CatC) inhibitor with enzyme and cell pIC50 of 8.4. |
| PC-42094 |
Aloxistatin
Cathepsin B inhibitor
|
Aloxistatin (E64d) is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets. |
| PC-45438 |
Leupeptin hemisulfate
Proteases inhibitor
|
Leupeptin hemisulfate is a potent, reversible inhibitor of cysteine, serine, and threonine proteases, inhibits cathepsin B (Ki=6 nM), calpain (Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 uM), and kallikrein (Ki=19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin. |
| PC-42108 |
CA-074 methyl ester
Cathepsin B inhibitor
|
CA-074 methyl ester is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM. |
| PC-42147 |
Odanacatib
Cathepsin K inhibitor
|
Odanacatib (MK-0822) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 0.2 nM. |
| PC-45577 |
MG-101
Cysteine proteases inhibitor
|
MG-101 (ALLN) is a potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM).
|
| PC-23639 |
IcatC
CatC inhibitor
|
IcatC (IcatCXPZ-01) is a potent, cell-permeable dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C (CatC, DPP1) with IC50 of 15 nM, selective over cathepsine H, K, L, S, NSPs and DPP4. |
| PC-22251 |
JNJ-10311795
Cathepsin G inhibitor
|
JNJ-10311795 is a potent dual inhibitor of neutrophil cathepsin G (Ki=38 nM) and mast cell chymase (Ki=2.3 nM), exhibits noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and LPS-induced airway inflammation. |
| PC-22250 |
Cathepsin G inhibitor KPA
Cathepsin G inhibitor
|
Cathepsin G inhibitor KPA is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (CatG) with IC50 of 53 nM. |
| PC-22165 |
ASP1617
Cathepsin S inhibitor
|
ASP1617 (ASP-1617) is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 4.6 nM and 0.39 nM for human and mouse CatS, respectively. |
