| Cat. No. |
Product Name |
Information |
| PC-27752 |
T16A(inh)-C01
TMEM16A inhibitor
|
T16A(inh)-C01 (T16Ainh-C01) is a specific small molecule calcium-activated chloride channel TMEM16A (ANO1, Anoctamin-1), blocks chloride channel mediated by ANO1 with IC50 of 8.4 uM. |
| PC-26735 |
NSC602247
HsCLIC1 inhibitor
|
NSC602247 is a small molecule inhibitor of human chloride intracellular channel 1 (HsCLIC1), binds to HsCLIC1 with micromolar affinity (6 uM), NSC602247 impairs HT29 cell growth and inhibits HsCLIC1 membrane translocation. |
| PC-23883 |
TMEM16A potentiator Fact
TMEM16A potentiator
|
TMEM16A potentiator Fact (Fact) is a potent small molecule potentiator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 6 uM. |
| PC-23882 |
TMEM16A activator Eact
TMEM16A activator
|
TMEM16A activator Eact (E(act)) is a small molecule activator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 3 uM. |
| PC-23881 |
PAM_16A
TMEM16A PAM
|
PAM_16A is a potent, selective, positive allosteric modulator of TMEM16A (Anoctamin-1, ANO1) with EC50 of 3.6 nM, activates heterologous TMEM16A channels, has no effect on the closely related TMEM16B channel. |
| PC-23810 |
Tamsulosin
TMEM16A inhibitor, α1-adrenergic receptor antagonist
|
Tamsulosin ((R)-(-)-YM12617 free base) is an effecive α1-adrenergic receptor antagonist, also demonstrates significant antiosteoporotic effects by inhibiting calcium-activated chloride channel TMEM16A. |
| PC-22007 |
NMD670
ClC-1 inhibitor
|
Ignaseclant (NMD670, NMD-670) is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG). |
| PC-21203 |
OV350
KCC2 activator
|
OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation. |
| PC-20482 |
K786-4469
TMEM16A inhibitor
|
K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo. |
| PC-20364 |
Ani9
TMEM16A inhibitor
|
Ani9 is a potent, selective anoctamin1 (ANO1, TMEM16A) channel inhibitor with IC50 of 107 nM, with negligible effect on ANO2 (IC50>10 uM). |
| PC-20363 |
CaCCinh-A01
CaCC/TMEM16A inhibitor
|
CaCCinh-A01 is a small molecule Ca(2+)-activated Cl(-) channel (CaCC) inhibitor, inhibits both I(sc) and transepithelial conductance in a concentration-dependent manner (IC50=6.3 uM). |
| PC-49192 |
TMEM16A blocker 1PBC
TMEM16A blocker
|
1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM). |
