| Cat. No. |
Product Name |
Information |
| PC-35990 |
T16Ainh-A01
TMEM16A inhibitor
|
T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM. |
| PC-35775 |
CLP290
KCC2 activator
|
CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257. |
| PC-35541 |
DRAinh-A250
SLC26A3 inhibitor
|
DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM. |
| PC-43155 |
IAA-94
Chloride channel inhibitor
|
IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM. |
| PC-62452 |
OADS
CLC Channel inhibitor
|
OADS is a specific, reversible, small-molecule inhibitor directs against CLC (Chloride Channel) antiporter with Ki of 29 uM, has no specific effect on a CLC channel (ClC-1). . |
| PC-62063 |
VU 0463271
KCC2 inhibitor
|
VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM. |
| PC-60024 |
CLP257
KCC2 activator
|
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM. |
| PC-47506 |
Chlorotoxin
Chloride channel inhibitor
|
Chlorotoxin is a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus). |
| PC-23883 |
TMEM16A activator F(act)
TMEM16A potentiator
|
TMEM16A activator F(act) (Fact) is a potent small molecule potentiator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 6 uM. |
| PC-23882 |
TMEM16A activator E(act)
TMEM16A activator
|
TMEM16A activator E(act) (Eact) is a small molecule activator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 3 uM. |
| PC-23881 |
PAM_16A
TMEM16A PAM
|
PAM_16A is a potent, selective, positive allosteric modulator of TMEM16A (Anoctamin-1, ANO1) with EC50 of 3.6 nM, activates heterologous TMEM16A channels, has no effect on the closely related TMEM16B channel. |
| PC-23810 |
Tamsulosin
TMEM16A inhibitor
|
Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α1-adrenergic receptor, also demonstrates significant antiosteoporotic effects by inhibiting calcium-activated chloride channel TMEM16A. |
