| Cat. No. |
Product Name |
Information |
| PC-20364 |
Ani9
TMEM16A inhibitor
|
Ani9 is a potent, selective anoctamin1 (ANO1, TMEM16A) channel inhibitor with IC50 of 107 nM, with negligible effect on ANO2 (IC50>10 uM). |
| PC-49192 |
TMEM16A blocker 1PBC
TMEM16A blocker
|
1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM). |
| PC-47048 |
TMinh-23
TMEM16A inhibitor
|
TMinh-23 is (Compound 10bm) is a potent, selective inhibitor of transmembrane protein 16A (TMEM16A or ANO1, DOG1, ORAOV2, TAOS-2) with IC50 of 30 nM in short-circuit current assays, weakly inhibits TMEM16B (IC50=400 nM, 13 -fold selectivity). |
| PC-38752 |
DRAinh-A270
SLC26A3 inhibitor
|
DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM. |
| PC-38691 |
VI-116
VRAC inhibitor
|
VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells. |
| PC-38479 |
MONNA
TMEM16A inhibitor
|
MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1). |
| PC-38096 |
Endovion
VRAC inhibitor
|
Endovion (Emidurdar, NS3728) is a volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM. |
| PC-35990 |
T16Ainh-A01
TMEM16A inhibitor
|
T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM. |
| PC-35775 |
CLP290
KCC2 activator
|
CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257. |
| PC-35541 |
DRAinh-A250
SLC26A3 inhibitor
|
DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM. |
| PC-43155 |
IAA-94
Chloride channel inhibitor
|
IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM. |
| PC-62452 |
OADS
CLC Channel inhibitor
|
OADS is a specific, reversible, small-molecule inhibitor directs against CLC (Chloride Channel) antiporter with Ki of 29 uM, has no specific effect on a CLC channel (ClC-1). . |
