Cat. No. |
Product Name |
Information |
PC-49192 |
TMEM16A blocker 1PBC
TMEM16A blocker
|
1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM). |
PC-38752 |
DRAinh-A270
SLC26A3 inhibitor
|
DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM. |
PC-38096 |
Endovion
|
Endovion (Emidurdar, NS3728) is a volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM. |
PC-35990 |
T16Ainh-A01
|
T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM. |
PC-35775 |
CLP290
KCC2 activator
|
CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257. |
PC-35541 |
DRAinh-A250
|
DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM. |
PC-62063 |
VU 0463271
KCC2 inhibitor
|
VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM. |
PC-60024 |
CLP257
KCC2 activator
|
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM. |
PC-22008 |
NMD670 sodium
ClC-1 inhibitor
|
NMD670 (NMD-670) sodium salt is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG). |
PC-22007 |
NMD670
ClC-1 inhibitor
|
NMD670 (NMD-670) is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG). |
PC-21203 |
OV350
KCC2 activator
|
OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation. |
PC-20364 |
Ani9
ANO1 (TMEM16A) inhibitor
|
Ani9 is a potent, selective anoctamin1 (ANO1, TMEM16A) channel inhibitor with IC50 of 107 nM, with negligible effect on ANO2 (IC50>10 uM). |